RESEARCH
“A Growing Body of Literature Supports the Broad Utility of
BioLife Products in the Biopreservation of Numerous Cell and
Tissue Types”
Hypothermic Storage Abstracts
Snyder, K.K., Baust, J.M., Van Buskirk, R.G., Baust, J.G.
Improved Hypothermic Storage of Sensitive Primary Cell Systems.
Cytotherapy, Vol. 7 Supp. 1, pg. 2, 2005.
Snyder, K.K., Baust, J.M., Van Buskirk, R.G., Baust, J.G.
"Assessment of Function and Metabolic Activity of Neonatal
Cardiomyocytes Following Hypothermic Storage", Cryobiology, Vol.
47 No. 3, pg. 273, 2003. (P.L. Steponkus Crystal Award
Recipient)
Mathew, A.J., Baust, J.G., and Van Buskirk, R.G. Enhanced
hypothermic preservation of human renal cells. Cryobiology
43:357 (2001).
Mathew, A.J., Baust, J.G., and Van Buskirk, R.G. Enhanced
hypothermic preservation of multiple human cell types.
Cryobiology 43:383 (2001).
Mathew, A. J., Baust, J. M., Hollister, W.R., Al-Abdullah, I.
H., Ricordi, C., Ban Buskirk, R. G., and Baust, J. G. Molecular
biological analysis of cell death leads to improvement in the
hypothermic solution, HypoThermosol. Cryobiology 41:335-6
(2000).
Mathew, A. J., Hollister, W. R., Baust, J. G., and Van Buskirk,
R. G. Continued optimization of the cold storage solution
HypoThermosol and implications of apoptosis. Cryobiology
37:398-9 (1998).
Wagerle, L.C., Taylor, M. J., Dahdah, N. S. and Russo, P.
Effects of ultraprofound hypothermia on the ex vivo contractile
response of cerebral arteries: Relevance to cerebrovascular
dysfunction during cardiopulmonary bypass. Cryobiology 35:346
(1997).
TTaylor, M. J., Snyder, M., Machen, L., and Baust, J. G.
Protective effect of high or low dose of butanedione monoxime
during hypothermic storage of isolated rabbit hearts.
Cryobiology 35(4), 345 (1997).
Elrifai, A. M., Taylor, M. J., Shih, S-R., Bailes, J. E., Kiya,
N., Wilberger, J. E., and Maroon, J. C. Hypothermic preservation
of immature spinal cord using HypoThermosol for transplantation
in the rat. Cryobiology 33:675 (1996).
Taylor, M. J., Snyder, M., Machen, L., Clark, R. E., and Baust,
J. G. Functional survival of isolated rabbit hearts after cold
storage in HypoThermosol modified with compounds that might
promote retention and repletion of high energy phosphates.
Cryobiology 33:620-1, (1996).
Taylor, M. J., Clark, R. E.; Snyder, M., Machen, L., and Baust,
J. G. Static cold storage of isolated rabbit hearts in
HypoThermosol: Influence of butanedione monoxime during
short-term storage. Cryobiology 32:538-9 (1995).
Van Buskirk, R. G., Taylor, M. J., Rauch, J., Roberts, S., and
Baust, J. G. Preservation of synthetic human skin in
HypoThermosol. Cryobiology 32:591 (1995).
SSimon, D., Taylor, M. J., Elrifai, A. M., Shih, S-R., Bailes, J.
E., Davis, D., Kluger, Y., and Diamond, D. L. Profound
hypothermia with blood substitution enables resuscitation after
hemorrhagic shock. ASAIO Journal 41:61 (1995).
Van Buskirk, R. G., Taylor, M. J., Shen, R., Tang, W., Mathew,
A., and Baust, J. G. Optimization of HypoThermosol using
cultured cardiomyocytes and the fluorescent multiple endpoint
assay. Cryobiology 32:590 (1995).
Taylor, M. J., Simon, D., Elrifai, A. M., Shih, S-R., Bailes, J.
E., Baust, J. G., Maroon, J. C., and Diamond, D. L. A
feasibility study in a canine model for using profound
hypothermia and blood substitution with HypoThermosol to enable
resuscitation after hemorrhagic shock. Cryobiology 31:592-3
(1994).
TTaylor, M. J., Clark, R. E., and Baust, J. G. The importance of
adenosine and glutathione as components of a new hypothermic
blood substitute (HypoThermosol): Evaluation of myocardial
protection at 7 degrees C using an isolated working rabbit heart
model. Cryobiology 30:593-4 (1994).
Elrifai, A. M., Bailes, J. E., Taylor, M. J., Shih, S. R.,
Teeple, E., Baust, J. G., and Maroon, J. C. Whole body
protection during ultraprofound hypothermic procedures using a
new intracellular-type aqueous blood substitute solution. Int
Soc Artif Cells Blood Substitute Immobil Technol (1993).
(submitted).
Elrifai, A., Bailes, J., Govindan, S., Teeple, E., Taylor, M.,
Shih, S., Leavitt, M., Adatepe, M., and Maroon, J. Evaluation of
cerebral blood flow using radioactive Xe133 after long term
survival of animals exposed to profound hypothermia and complete
blood substitution. Soc. Neurosci. Abst 18:1221 (1993).
Elrifai, A. M., Bailes, J. E., Maroon, J. C., Shih, S., Taylor,
M. J., Teeple, E., Leavitt, M. L., and Ciongoli, K. A. The
correlation of warming with outcome in an experimental canine
model of profound hypothermia involving blood substitution and
cardiac arrest. Cryobiology 30:642-3 (1993).
Elrifai, A. M., Bailes, J. E., Teeple, E., Taylor, M. J., Shih,
S-R., Leavitt, M. L., and Maroon, J. C. Monitoring cerebral
perfusion pressure in experimental profound hypothermia and
cardiac arrest. Cryobiology 30:643 (1993).
Elrifai, A. M., Bailes, J. E., Taylor, M. J., Teeple, E., Shih,
S-R., Leavitt, M. L., Baust, J. G., and Maroon, J. C. New
aqueous blood substitutes for general tissue preservation during
3 hours of profound hypothermic cardiac arrest: II. Methods and
neurological outcome. Cryobiology 30:656 (1993).