CD34 &#x2212;  human placenta-derived mesenchymal stem cells protect against heat stroke mortality in rats

Willie Lin; Yogi Chang-Yo Hsuan; Yu-Chin Su; Cheng-Hsien Lin; Mao-Tsun Lin; Zi-Hao Chen; Ching-Ping Chang; Kao-Chang Lin

doi:10.18632/oncotarget.23324

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Research Papers:

CD34⁻ human placenta-derived mesenchymal stem cells protect against heat stroke mortality in rats

Willie Lin, Yogi Chang-Yo Hsuan, Yu-Chin Su, Cheng-Hsien Lin, Mao-Tsun Lin, Zi-Hao Chen, Ching-Ping Chang _ and Kao-Chang Lin

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Oncotarget. 2018; 9:1992-2001. https://doi.org/10.18632/oncotarget.23324

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Abstract

Willie Lin1, Yogi Chang-Yo Hsuan1, Yu-Chin Su1, Cheng-Hsien Lin1, Mao-Tsun Lin2, Zi-Hao Chen3,4, Ching-Ping Chang2,4,5 and Kao-Chang Lin4,6

1Meridigen Biotech Co., Ltd., Taipei, Taiwan

2Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan

3Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

4Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan

5The Ph.D. Program for Neural Regenerative Medicine, Taipei Medical University, Taipei, Taiwan

6Department of Neurology, Chi Mei Medical Center, Tainan, Taiwan

Correspondence to:

Ching-Ping Chang, email: [email protected], [email protected]

Kao-Chang Lin, email: [email protected]

Keywords: heat stroke; placenta; mesenchymal stem cells; ischemia; inflammation

Received: August 24, 2017 Accepted: December 09, 2017 Published: December 15, 2017

ABSTRACT

CD34 is a transmembrane phosphoglycoprotein used to selectively enrich bone marrow in hematopoietic stem cells for transplantation. Treating rats with CD34⁺ cells derived from human umbilical cord blood before or after heat stroke has been shown to promote survival. We investigated whether CD34^– human placenta-derived stem cells (PDMSCs) could improve survival following heat stroke in rats. Rats were subjected to heat stress (42°C for 98 min) to induce heat stroke. Intravenous administration of PDMSCs 1 day before or immediately after the onset of heat stroke improved survival by 60% and 20%, respectively. Pre-treatment with CD34⁻ PDMSCs protected against heat stroke injury more effectively than that treatment after injury. PDMSCs treatment attenuated cerebrovascular dysfunction, the inflammatory response, and lipid peroxidation. These data suggest human PDMSCs protect against heat stroke injury in rats. Moreover, these effects do not require the presence of CD34⁺ cells.

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Abstract

CD34⁻ human placenta-derived mesenchymal stem cells protect against heat stroke mortality in rats