Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans

Charlesworth, C. T., Deshpande, P. S., Dever, D. P., Camarena, J., Lemgart, V. T., Cromer, M. K., Vakulskas, C. A., Collingwood, M. A., Zhang, L., Bode, N. M., Behlke, M. A., Dejene, B., Cieniewicz, B., Romano, R., Lesch, B. J., Gomez-Ospina, N., Mantri, S., Pavel-Dinu, M., Weinberg, K. I., Porteus, M. H.  Identification of Pre-Existing Adaptive Immunity to Cas9 Proteins in Humans.  Nature Medicine. 2019; 25, 249-254.  doi:10.1038/s41591-018-0326-x

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