Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells

Weber, E. W., Lynn, R. C., Parker, K. R., Anbunathan, H., Lattin, J., Sotillo, E., Good, Z., Malipatlolla, M., Xu, P., Vandris, P., Majzner, R. G., Qi, Y., Chen, L., Gentles, A. J., Wandless, T. J., Satpathy, A. T., Chang, H. Y. and Mackall, C. L.  Transient “rest” induces functional reinvigoration and epigenetic remodeling in exhausted CAR-T cells.  Science. 2021 Apr 2; 372(6537), eaba1786.  doi: 10.1126/science.aba1786