Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

Powers, R. K., Culp-Hill, R., Ludwig, M. P., Smith, K. P., Waugh, K. A., Minter, R., Tuttle, K. D., Lewis, H. C., Rachubinski, A. L., Granrath, R. E., Carmona-Iragui, M., Wilkerson, R. B., Kahn, D. E., Joshi, M., Lleó, A., Blesa, R., Fortea, J., D’Alessandro, A., Costello, J. C., Sullivan, K. D., Espinosa, J. M.  Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.  Nature Communications. 2019; 10(1).  doi:10.1038/s41467-019-12739-9