Cryopreservation
Freeze Media

Wali, G., Siow, SF, Liyanage, E., Kumar, KR, Mackay-Sim, A. and Sue, CM. Reduced Acetylated Α-Tubulin In Spast Hereditary Spastic Paraplegia Patient Pbmcs. Frontiers in Neuroscience, 2023:17:1073516. Mar-23.

Holicek, P., Truxova, I., Rakova, J., Salek, C., Hensler, M., Kovar, M., Reinis, M., Mikyskova, R., Pasulka, J., Vosahlikova, S., Remesova, H., Valentova, I., Lysak, D., Holubova, M., Kaspar, P., Prochazka, J., Kasikova, L., Spisek, R., Galluzzi, L., and Fucikova, J. Type I Interferon Signaling In Malignant Blasts Contributes To Treatment Efficacy In Aml Patients. Cell Death and Disease, 2023:14:209. Mar-23.

McAuley, GE, Yiu, G., Chang, PC, Newby, GA, Campo-Fernandez, B., Fitz-Gibbon, ST, Wu, X., Kang, S-H L, Garibay, A., Butler, J., Christian, V., Wong, RL, Everette, KA, Azzun, A., Gelfer, H., Seet, CS, Narendran, A., Murguia-Favela, L., Romero, Z., Wright, N., Liu, DR, Crooks, GM, Kohn, DB. Human T Cell Generation Is Restored In Cd3Δ Severe Combined Immunodeficiency Through Adenine Base Editing. Cell, 2023:186:7, 1398-1416. Mar-23.

Quijano, JC, Wedeken, L., Ortiz, JA, Zook, HN, LeBon, JM, Luo, A., Rawson, J., Tremblay, JR, Mares, JM, Lopez, K., Chen, M-H, Jou, K., Mendez-Dorantes, C., Al-Abdullah, IH, Thurmond, DC, Kandeel, F., Riggs, AD, and Ku, HT. Methylcellulose Colony Assay And Single-Cell Micro-Manipulation Reveal Progenitor-Like Cells In Adult Human Pancreatic Ducts. Stem Cell Reports, 2023:18, 1-18. Mar-23.

Puig-Saus, C., Sennino, B., Peng, S., Wang, CL, Pan, Z., Yuen, B., Purandare, B., An, D., Quach, BB, Nguyen, D., Xia, H., Jilani, S., Shao, K., McHugh, C., Greer, J., Peabody, P., Nayak, S., Hoover, J., Said, S., Jacoby, K., Dalmas, O., Foy, SP, Conroy, A., Yi, MC, Shieh, C., Lu, W., Heeringa, K., Ma, Y., Chizari, S., Pilling, MJ, Ting, M., Tunuguntla, R., Sandoval, S., Moot, R., Hunter, T., Zhao, S., Saco, JD, Perez-Garcilazo, I., Medina, E., Vega-Crespo, A., Baselga-Carretero, I., Abril-Rodriguez, G., Cherry, G., Wong, DJ, Hundal, J., Chmielowski, B., Speiser, DE, Bethune, MT, Bao, XR, Gros, A., Griffith, OL, Griffith, M., Heath, JR, Franzusoff, A., Mandl, SJ, Ribas, A. Neoantigen-Targeted Cd8+ T Cell Responses With Pd-1 Blockade Therapy. Nature, 2023. Mar-23.

Jimeno, A., Baranda, J., Iams, J.W., Park, J.C., Mita, M., Gordon, M.S., Taylor, M. Dhani, N., Leal, A.D., Neupane, P. Eng, C., Yeku, O., Mita, A., Moser, J.C., Butler, M., Loughhead, S.M., Jennings, J. Miselis, N.R., Ji, R-R, Nair, N., Kornacker, M., Zwirtes, R.F., Bernstein, H., Sharei, A. Phase 1 Study To Determine The Safety And Dosing Of Autologous Pbmcs Modified To Present Hpv16 Antigens (Sqz-Pbmc-Hpv) In Hla-A*02+ Patients With Hpv16+ Solid Tumors. Investigational New Drugs, 2023. May-23.

Rhiel M., Geiger K., Andrieux G., Rositzka J., Boerries M., Cathomen T. and Cornu T.I. T-Cast: An Optimized Cast-Seqpipeline For Talen Confirmssuperior Safety And Efficacy Ofobligate-Heterodimeric Scaffolds. Frontiers in Genome Editing, 2023:5:1130736. Feb-23.

Danielli, S.G., Porpiglia, E., De Micheli, A.J., Navarro, N., Zellinger, M.J., Bechtold, I., Kisele, S., Volken, L., Marques, J.G., Kasper, S., Bode, P.K., Henssen, A.G., Gürgen, D., Delattre, O., Surdez, D., Roma, J., Bühlmann, P., Blau, H.M., Wachtel, M., Schäfer, B.W. Single-Cell Profiling Of Alveolar Rhabdomyosarcoma Reveals Ras Pathway Inhibitors As Cell-Fate Hijackers With Therapeutic Relevance. Science Advances, 2023:9:6. Feb-23.

Wynn, L. , Wilson, M.G. , Leonforte, C. Manufacturing Of Cd34 + Hpc-Enriched, High-Purity Mononuclear Cell Products From Umbilical Cord Blood. Cell Tissue Bank, 2023: Feb 3. Feb-23.

Mitchell, C.A., Verovskaya, E.V., Calero-Nieto, F.J., Olson, O.C., Swann, J.W., Wang, X., Hérault, A., Dellorusso, P.V., Zhang, S.Y., Svendsen, A.F., Pietras, E.M., Bakker, S.T., Ho, T.T., Göttgens, B. & Passegué, E. Stromal Niche Inflammation Mediated By Il-1 Signalling Is A Targetable Driver Of Haematopoietic Ageing. Nature Cell Biology, 2023: 25, 30–41. Jan-23.

Depuydt, M.A.C., Schaftenaar, F.H., Prange, K.H.M., Boltjes, A., Hemme, E., Delfos, L., de Mol, J., de Jong, M.J.M., Bernabé Kleijn, M.N.A., Peeters, J.A.H.M., Goncalves, L., Wezel, A., Smeets, H.J., de Borst, G.J., Foks, A.C., Pasterkamp, G., de Winther, M.P.J., Kuiper, J., Bot, I. & Slütter, B. Single-Cell T Cell Receptor Sequencing Of Paired Human Atherosclerotic Plaques And Blood Reveals Autoimmune-Like Features Of Expanded Effector T Cells. Nature Cardiovascular Reseearch, 2023. Jan-23.

Vitanza1 N.A., Wilson, A.L., Huang, W., Seidel, K., Brown, C., Gustafson, J.A., Yokoyama, J.K., Johnson, A.J., Baxter, B.A., Koning, R.W., Reid, A.N., Meechan, M., Biery, M.C., Myers, C., Rawlings-Rhea, S.D., Albert, C.M., Browd, S.R., Hauptman, J.S., Lee, A., Ojemann, J.G., Berens, M.E., Dun, M.D., Foster, J.B., Crotty, E.E., Leary, S.E.S., Cole, B.L., Perez, F.A., Wright, J.N., Orentas, R.J., Chour, T., Newell, E.W., Whiteaker, J.R., Zhao, L., Paulovich, A.G., Pinto, N., Gust, J., Gardner, R.A., Jensen, M.C., and Park, J.R. Intraventricular B7-H3 Car T Cells For Diffuse Intrinsic Pontine Glioma: Preliminary First-In-Human Bioactivity And Safety. Cancer Discovery, 2023: 13:114–31. Oct-22.

Jae-Seung Moon 1,2,11, Shady Younis 1,2,3,11, Nitya S. Ramadoss1,2,
Radhika Iyer 1,2, Khushboo Sheth 1,2, Orr Sharpe1,2, Navin L. Rao4,
Becart, S., Carman, J.A., James, E.A., Buckner, J.H., Deane, K.D., Holers, V.M., Goodman, S.M., Donlin, L.T., Davis, M.M., & Robinson, W.H. Cytotoxic Cd8+ T Cells Target Citrullinated Antigens In Rheumatoid Arthritis. Nature Communications, 2023:4:319. Jan-23.

Li, Q, Yang, C., Tian, H., Jiang, J., Li, P., Zhu, X., Lei, T., Yin, R., Ding, P., Bai, P., Li, Q. Development Of A Personalized Dendritic Cell Vaccine And Single-Cell Rna Sequencing-Guided Assessment Of Its Cell Type Composition. Cytotherapy, 2023:25:210-219. Dec-22.

Liao, J., Chen, S., Hsiao, S., Jiang, Y., Yang, Y., Zhang, Y., Wang, X., Lai, Y., Bauer, D.E., Wu, Y. Therapeutic Adenine Base Editing Of Human Hematopoietic Stem Cells. Nature Communications, 2023:14:207. Jan-23.

Dreyzin, A., Panch, S.R., Shalabi, H., Yates, B., Highfill, S.L., Jin, P., Stroncek, D., and Shah, N.N. Cryopreserved Anti-Cd22 And Bispecific Anti-Cd19/22 Car T Cells Are As Effective As Freshly Infused Cells. Molecular Therapy: Methods & Clinical Development, 2023:28:51. Dec-22.

Matlock, A.D., Vaibhav,V., Holewinski, R., Venkatraman,V., Dardov, V., Manalo, D-M., Shelley, B., Ornelas, L., Banuelos, M., Mandefro, B., Escalante-Chong, R., Li, J., Finkbeiner, S., Fraenkel, E., Rothstein, J., Thompson, L., Sareen, D., Svendsen, C.N., NIH NeuroLINCS Consortium & Van Eyk, J.E. Neurolincs Proteomics: Defining Human-Derived Ipsc Proteomes And Protein Signatures Of Pluripotency. Nature Scientific Data, 2023:10:24. Jan-23.

Follin, B., Hoeeg, C., Hunter, I., Bentsen, S., Juhl, M., Jensen, J.K., Binderup, T., Nielsen, C.H., Ripa, R.S., Kastrup, J.; Ekblond, A., and Kjaer, A. [68Ga]Ga-Nodaga-E[(Crgdyk)]2 And [64Cu]Cu-Dotatate Pet Predict Improvement In Ischemic Cardiomyopathy. Diagnostics, 2023:13:268. Jan-23.

Sypecka, M., Bzinkowska, A., Sulejczak, D., Dabrowski, F., Sarnowska, A. Evaluation Of The Optimal Manufacturing Protocols And Therapeutic Properties Of Mesenchymal Stem/Stromal Cells Derived From Wharton’S Jelly. International Journal of Molecular Sciences, 2023:24:652. Dec-22.

Skurikhin, E.G., Pershina, O.; Ermakova, N., Pakhomova, A., Zhukova, M., Pan, E., Sandrikina, L., Widera, D., Kogai, L., Kushlinskii, N., Kubatiev, A., Morozov, S.G., and Dygai, A. Cell Therapy With Human Reprogrammed Cd8+ T-Cells Has Antimetastatic Effects On Lewis Lung Carcinoma In C57Bl/6 Mice. International Journal of Molecular Sciences, 2022:23:15780. Dec-22.

Fujii, S., Endo, K., Ozeki, N., Sakamaki, Y., Kohno, Y., Mizuno, M., Katano, H., Tsuji, K., Koga, H. and Sekiya, I. Comparison Of Adhesion Of Thawed And Cultured Synovial Mesenchymal Stem Cells To The Porcine Meniscus And The Relevance Of Cell Surface Microspikes. BMC Molecular and Cell Biology, 2022:23:53. Dec-22.

Lynggaard, C.D., Jersie-Christensen, R., Juhl , M., Jensen, S.B., Grønhøj, C., Melchiors, J., Jacobsen, S., Møller-Hansen, M., Herly, M., Ekblond, A., Kastrup, J., Fischer-Nielsen, A., Belstrøm, D. & von Buchwald, C. Intraglandular Mesenchymal Stem Cell Treatment Induces Changes In The Salivary Proteome Of Irradiated Patients. Comminciations Medicine, 2022:2:160. Dec-22.

Rosinski, J.R., Raasch, L.E., Tiburcio, P.B., Breitbach, M.E., Shepherd, P.M., Yamamoto, K., Razo, E., Krabbe, N.P., Bliss, M.I., Richardson, A.D., Einwalter, M.A., Weiler, A.M., Sneed, E.L., Fuchs, K.B., Zeng, X., Noguchi, K.K., Morgan, T.K., Alberts, A.J., Antony, K.M., Kabakov, S., Ausderau, K.K., Bohm, E.K., Pritchard,J.C., Spanton, R.V, Ver Hoove, J.N., Kim, C.B.Y., Nork, T.M., Katz, A.W., Rasmussen, C.A., Hartman, A., Mejia, A., Basu, P., Simmons, H.A., Eickhoff, J.C., Friedrich, T.C., Aliota, M.T., Mohr, E.L., Dudley, D.M., O’Connor, D.H. &, Newman, C.M. Frequent First-Trimester Pregnancy Loss In Rhesus Macaques Infected With African-Lineage Zika Virus. Dec-22.

Hansen SB, Højgaard LD, Kastrup J, Ekblond A, Follin B and Juhl M. Optimizing An Immunomodulatory Potency Assay For Mesenchymal Stromal Cell. Frontiers in Immunology, 2022,13:1085312. Dec-22.

Cooper, A, Sidaway, A., Chandrashekar, A., Latta, E., Chakraborty, K., Yu, J., McMahan, K., Giffin, V., Manickam, C., Kroll, K., Mosher, M., Reeves, R.K., Gam, R., Arthofer, E., Choudhry, M., Henley, T., and Barouch, D.H. A Genetically Engineered, Stem-Cell-Derived Cellular Vaccine. Cell Reports Medicine. 2022, 3:100843. Dec-22.

Nettersheim, F.S., Armstrong , S.S., Durant, C., Blanco‑Dominguez, R., Roy, P., Orecchioni, M., Suryawanshi, V, Ley, K. Titration Of 124 Antibodies Using Cite-Seq On Human Pbmcs. Scientific Reports. 2022, 12:20817. Dec-22.

Keller, A-L., Greis, D., Eybe, J., Plöger, S., Weiss, M., Koch, A., Brucker, S.Y., Schenke-Layland, K., Schmees, C. Generation And Characterization Of Three Induced Pluripotent Stem Cells Lines From An 86-Year Old Female Individual Diagnosed With An Invasive Lobular Mammary Carcinoma. Dec-22.

Berber, P., Bondarenko, S., Michaelis, L., Weber, B.H.F. Transient Retention Of Photoreceptor Outer Segments In Matrigel-Embedded Retinal Organoids. International Journal of Molecular Sciences. 2022, 23:14893. Nov-22.

Lee, J.-H., Park, H.-J., Kim, Y.-A., Lee, D.-H., Noh, J.-K., Jung, J.-G., Yoon, H.-H., Lee, S.-K., Lee, S. Establishment Of A Serum-Free Hepatocyte Cryopreservation Process For The Development Of An “Off-The-Shelf” Bioartificial Liver System. Bioengineering. 2022, 9:738. Nov-22.

Bibby,J.A., Agarwal, D., Freiwald, T., Kunz, N., Merle, N.S., West, E.E., Larochelle, A., Chinian, F., Mukherjee, S., Afzali, B., Kemper, C., Zhang, N.R. Systematic Single Cell Pathway Analysis (Scpa) Reveals Novel Pathways Engaged During Early T Cell Activation. Feb-22.

Chua, K.J., Ling, H., Hwang, I.Y., Lee, H.L., March, J.C., Lee, Y.S., and Chang, M.W. An Engineered Probiotic Produces A Type Iii Interferon Ifnl1 And Reduces Inflammations In In Vitro Inflammatory Bowel Disease Models. Nov-22.

Najafabadi, M.G., Gray, G.K., Kong, L.R., Gupta, K., Perera, D., Brugge, J.S., Venkitaraman, A., Shehata, M. A Transcriptional Response To Replication Stress Selectively Expands A Subset Of Brca2-Mutant Mammary Epithelial Cells. Nov-22.

Khan, S., Salisch, N.C., Gil, A.I., Boedhoe, S., Feddes-de Boer, K., Serroyen, J., Schuitemaker, H., and Zahn, R.C. Sequential Use Of Ad26-Based Vaccine Regimens In Nhp To Induce Immunity Against Different Disease Targets. npj Vaccines. 2022; 7:146. Nov-22.

Sureshchandra, S., Chan, C.N., Robino, J.J., Parmelee, L.K., Nash, M.J., Wesolowski, S.R., Pietras, E.M., Friedman, J.E., Takahashi, D., Shen, W., Jiang,, X., Hennebold, J.D., Goldman, D., Packwood, W., Lindner, J.R., Roberts, Jr., C.T., Burwitz,B.J., Messaoudi, I., and Varlamov, O. Maternal Western-Style Diet Remodels The Transcriptional Landscape Of Fetal Hematopoietic Stem And Progenitor Cells In Rhesus Macaques. Stem Cell Reports. 2022, 17 :1–15. Nov-22.

Jung, N., Park, S., Kong, T., Park, H., Seo, W.M., Lee, S., Kang, K-S. Lc-Ms/Ms-Based Serum Proteomics Reveals A Distinctive Signature In A Rheumatoid Arthritis Mouse Model After Treatment With Mesenchymal Stem Cells. PLoS ONE. 2022, 17(11): e0277218. Nov-22.

Siddharth Subham, S., Jeppson, J.D., Worcester, C., Schatmeyer, B., Zhao, Madan, R., Lakis, N., Kimler, B., McGuirk, J.P., Chen, R.C.C., Stecklein, S.R., Akhavan, D. Egfr As A Potent Car T Target In Triple Negative Breast Cancer Brain Metastases. Nov-22.

Noorman, F., Rijnhout, T.W.H., de Kort, B., Hoencamp, R. Frozen For Combat: Quality Of Deep-Frozen Thrombocytes, Produced And Used By The Netherlands Armed Forces 2001–2021. Transfusion. 2022, 1–14. Nov-22.

Ravindranathan, S., Passang, T., Li, J-M, Wang, S., Dhamsania, R., Ware, M.B., Zaidi, M.Y., Zhu, J., Cardenas, M., Liu, Y., Gumber, S., Robinson, B., Sen-Majumdar, A., Zhang, H., Chandrakasan, S., Kissick, H., Frey, A.B., Thomas, S.N., El-Rayes, B.F., Lesinski, G.B. & Waller, E.K. Targeting Vasoactive Intestinal Peptidemediated Signaling Enhances Response To Immune Checkpoint Therapy In Pancreatic Ductal Adenocarcinoma. Nature Communications. 2022, 13:6418. Oct-22.

Rodenburg, L.W., Delpiano, L.; Railean, V., Centeio, R., Pinto, M.C., Smits, S.M.A., van derWindt, I.S., van Hugten, C.F.J., van Beuningen, S.F.B., Rodenburg, R.N.P., van der Ent, C.K., Amaral, M.D. , Kunzelmann, K., Gray, M.A., Beekman, J.M., and Amatngalim, G.D. Drug Repurposing For Cystic Fibrosis: Identification Of Drugs That Induce Cftr-Independent Fluid Secretion In Nasal Organoids. International Journal of Molecular Sciences. 2022, 23:12657. Oct-22.

Rabold, K., Zoodsma, M., Grondman, I., Kuijpers, Y., Bremmers, M., Jaeger, M., Zhang, B., Hobo, W., Bonenkamp, de Wilt, H.J.W., Janssen, M.J.R., Cornelissen, L.A.M., Ivan Engen-vanGrunsven, I.C.H., Mulder, W.J.M., Smit, J.W.A., Adema, G.J., Netea, M.G., Li, Y., Xu, C-J, & Netea-Maier, R.T. Reprogramming Of Myeloid Cells And Their Progenitors In Patients With Non-Medullary Thyroid Carcinoma. Nature Communications. 2022, 13:6149. Oct-22.

Kumar, S. & Meneghel, J. Optimizing And Standardizing The Cryopreservation Of Cellular Samples: New Data And Insights From The Uk’S Advanced Therapy Treatment Centres Network Programme. Cell & Gene Therapy Insights. 2022, 8:6:967–976. Oct-22.

Cunningham, A.W., Jones, M., Frank, N., Sethi, D, Miller, M.M. Stem-Like Memory T Cells Are Generated During Hollow Fiber Perfusion-Based Expansion And Enriched After Cryopreservation In An Automated Modular Cell Therapy Manufacturing Process. Cytotherapy. 2022, 24;1148-1157. Oct-22.

Fleck, J.S., Jansen, S.M.J., Wollny, D., Zenk, F., Seimiya, M., Jain, A., Okamoto, R., Santel, M., He, Z., Camp, J.G. & Treutlein, B. Inferring And Perturbing Cell Fate Regulomes In Human Brain Organoids. Nature. 2022, 1476-4687. Oct-22.

Yang, S.J., Singh, A.K., Drow, T., Tappen, T., Honaker, Y., Barahmand-Pour-Whitman, F., Linsley, P.S., Cerosaletti, K., Mauk, K., Xiang, Y., Smith, J., Mortensen, E., Cook, P.J. , Sommer, K. , Khan, I., Liggitt, D., Rawlings, D.J. , Buckner, J.H. Pancreatic Islet-Specific Engineered Tregs Exhibit Robust Antigen-Specific And Bystander Immune Suppression In Type 1 Diabetes Models. Science Translational Medicine. 2002, 14:665, eabn1716. Oct-22.

Brezinger-Dayan, K., Itzhaki, O., Melnichenko, J., Kubi, A., Zeltzer, L., Jacoby, E., Avigdor, A., Shapira Frommer, R. and Besser, M.J. Impact Of Cryopreservation On Car T Production And Clinical Response. Frontiers in Oncology. 2022, 12:1024362. Oct-22.

Skurikhin, E.G., Ermakova, N., Zhukova, M., Pershina, O., Pan, E., Pakhomova, A., Kogai, L., Goldberg, V., Simolina, E., Skurikhina, V, Widera, D. , Kubatiev, A., Morozov, S.G., Kushlinskii, N., and Dygai, A. Analysis Of Circulating Tumor And Cancer Stem Cells Provides New Opportunities In Diagnosis And Treatment Of Small Cell Lung Cancer. International Journal of Molecular Sciences. 2022, 23:10853. Sep-22.

Juhl, M., Follin, B., Christensen, J.P., Kastrup, J., Ekblond, A. Functional In Vitro Models Of The Inhibitory Effect Of Adipose Tissue-Derived Stromal Cells On Lymphocyte Proliferation: Improved Sensitivity And Quantification Through Flow Cytometric Analysis. Journal of Immunological Methods. 2022, 510:113360, ISSN 0022-1759. Sep-22.

An, Z. , Gicobi, J.K., Harrington, S.M., Zhang, H., Xu, T. , Hirdler , J., Lohse, C. , Leibovich, B.C., Dong, H., Lucien, F. Discovery Of A Novel Monoclonal Pd-L1 Antibody H1A That Promotes T-Cell Mediated Tumor Killing Activity In Renal Cell Carcinoma. Sep-22.

Najimi, M , Michel, S., Binda, M.M. , Gellynck, K., Belmonte, N., Mazza, G., Gordillo, N. , Vainilovich, Y., and Sokal, E. Human Allogeneic Liver-Derived Progenitor Cells Significantly Improve Nafld Activity Score And Fibrosis In Late-Stage Nash Animal Model. Cells. 2022, 11:2854. Sep-22.

Good, Z., Spiegel, J.Y., Sahaf, B., Malipatlolla, M.B., Ehlinger, Z.J., Kurra, S., Desai, M.H., Reynolds, W.D., Lin, A.W., Vandris, P., Wu, F., Prabhu, S., Hamilton, M.P., Tamaresis, J.S., Hanson, P.J., Patel, S., Feldman, S.A., Frank, M.J., Baird, J.H., Muffly, L., Claire, G.K., Craig, J., Kong, K.A., Wagh, D., Coller, J. Bendall, S.C., Plevritis, S.K., Miklos, D.B., Mackall, C.L. Post-Infusion Car T Reg Cells Identify Patients Resistant To Cd19-Car Therapy. Nature Medicine. 2022, 28:1860–1871. Sep-22.

Su, T., Duran, G.E., Kwang, A.C., Ramchurren, N., Fling, S.P., Kim, Y.H., & Khodadoust, M.S. Single-Cell Rna-Sequencing Reveals Predictive Features Of Response To Pembrolizumab In Sézary Syndrome. OncoImmunology. 2022, 11:1, e2115197. Aug-22.

Michaels, Y.S., Edgar, J.M., Major, M.C., Castle, E.L., Zimmerman, C., Yin, T., Hagner, A., Lau, C., Hsu, H.H., Ibañez-Rios, M.I., Durland, L.J., Knapp, D.J.H.F., Zandstra, P.W. Dll4 And Vcam1 Enhance The Emergence Of T Cell–Competent Hematopoietic Progenitors From Human Pluripotent Stem Cells. Science Advances. 2022, 8, eabn5522. Aug-22.

Cutrupi, A.N., Narayanan, R.K., Perez-Siles, G. , Grosz, B.R. , Lai, K., Boyling, A., Ellis, M., Lin, R. CY, Neumann , B., Mao, D., Uesugi, M., Nicholson, G.A., Vucic, S., Saporta, M.A., Kennerson, M.L. Novel Gene-Intergenic Fusion Involving Ubiquitin E3 Ligase Ube3C Causes Distal Hereditary Motor Neuropathy: A New Mechanism For Motor Neuron Degeneration. Aug-22.

Obach, D., Solastie, A., Liedes, O., Vara, S., Krzyżewska‐Dudek, E., Brinkmann, L., Haveri, A., Hammer, C.C., Dub, T., Meri, S., Freitag, T.L., Lyytikäinen, O., Melin, M. Impaired Immunity And High Attack Rates Caused By Sars‐Cov‐2 Variants Among Vaccinated Long‐Term Care Facility Residents. Immunity, Inflammation and Disease. 2022, 10:e679. Aug-22.

Palmer, C.D., Rappaport, A.R., Davis, M.J., Hart, M.G., Scallan, C.D., Hong, S-J, Gitlin, L., Kraemer, L.D., Kounlavouth, S., Yang, A., Smith, L., Schenk, D., Skoberne, M., Taquechel, K., Marrali, M., Jaroslavsky,J.R., Nganje, C.N., Maloney, E., Zhou, R., Navarro-Gomez, D., Greene, A.C., Grotenbreg, G., Greer, R., Blair, W., Cao, M.D., Chan, S., Bae, K., Spira, A.I., Roychowdhury, S., Carbone, D.P., Henick, B.S., Drake, C.G., Solomon, B.J., Ahn, D.H., Mahipal, A., Maron, S.B., Johnson, B., Rousseau, R., Yelensky, R., Liao, C-Y, Catenacci, D.V.T., Allen, A, Ferguson, A.R., and Jooss, K. Individualized, Heterologous Chimpanzee Adenovirus And Self-Amplifying Mrna Neoantigen Vaccine For Advanced Metastatic Solid Tumors: Phase 1 Trial Interim Results. Nature Medicine. 2022, 28:1619–1629. Aug-22.

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Menon, R., Otto, E. A., Berthier, C. C., Nair, V., Farkash, E. A., Hodgin, J. B., Yang, Y., Luo, J., Woodside, K. J., Zamani, H., Norman, S. P., Wiggins, R. C., Kretzler, M. and Naik, A. S. Glomerular endothelial cell-podocyte stresses and crosstalk in structurally normal kidney transplants. Kidney International. 2022. doi: 10.1016/j.kint.2021.11.031

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Chen, H., Chen, Y., Yu, S., Lai, W., Shen, Y., Shen, P., Lin, S., Chang, C. and Lee, S. Infrapatellar fat pad-derived mesenchymal stromal cell product for treatment of knee osteoarthritis: a first-in-human study with evaluation of the potency marker. Cytotherapy. 2021; 24(1), pp. 72-85. doi: 10.1016/j.jcyt.2021.08.006

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Schaniel, C., Papa, L., Meseck, M. L., Kintali, M., Djedaini, M., Zangui, M., Iancu-Rubin, C. and Hoffman, R.  Evaluation of a clinical-grade, cryopreserved, ex vivo-expanded stem cell product from cryopreserved primary umbilical cord blood demonstrates multilineage hematopoietic engraftment in mouse xenografts.  Cytotherapy. 2021; 23(9), 841-851.  doi: 10.1016/j.jcyt.2021.04.001

Gilfanova, R., Auclair, K. M., Hui, A., Norris, P. J. and Muench, M. O. Reduced dimethyl sulfoxide concentrations successfully cryopreserve human hematopoietic stem cells with multi-lineage long-term engraftment ability in mice. Cytotherapy. 2021; 23(12), 1053-1059. doi: 10.1016/j.jcyt.2021.07.007

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Bluhmki, T., Traub, S., Müller, A., Bitzer, S., Schruf, E., Bammert, M., Leist, M., Gantner, F., Garnett, J. P. and Heilker, R.  Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air–liquid interface model.  Scientific Reports. 2021; 11(1).  doi: 10.1038/s41598-021-96565-4

Nagarathinam Selvaraj, Chao-Kuei Wang, Brian Bowser, Trevor Broadt, Samir Shaban, Jenna Burns, Nirmala Saptharishi, Peter Pechan, Diane Golebiowski, Asaf Alimardanov, Nora Yang, George Mitra, and Ramarao Vepachedu.  Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.  Human Gene Therapy. 2021; 32(15-16), 850-861.  doi: 10.1089/hum.2020.054

Dumas, P., Villacreces, A., Guitart, A. V., El-habhab, A., Massara, L., Mansier, O., Bidet, A., Martineau, D., Fernandez, S., Leguay, T., Pigneux, A., Vigon, I., Pasquet, J. and Desplat, V. Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia.  Clinical Cancer Research. 2021; 27:6012-25. doi: 10.1158/1078-0432.ccr-20-3114

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Tian E., Zhang M., and Shi Y. Direct Reprogramming of Fibroblasts to Astrocytes Using Small Molecules.  In: Ahlenius H. (eds) Neural Reprogramming. Methods in Molecular Biology. 2021; vol 2352, pp. 45-55. Humana, New York, NY.  doi: 10.1007/978-1-0716-1601-7_4

Quist E., Ahlenius H., and Canals I.  Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons.  In: Ahlenius H. (eds) Neural Reprogramming. Methods in Molecular Biology. 2021; vol 2352, pp. 133-148. Humana, New York, NY.  doi: 10.1007/978-1-0716-1601-7_10

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Keddache, S., Laheurte, C., Boullerot, L., Laurent, L., Dalphin, J., Adotevi, O. and Soumagne, T.  Inflammatory and immunological profile in COPD secondary to organic dust exposure.  Clinical Immunology. 2021; 108798.  doi: 10.1016/j.clim.2021.108798

Giacomelli, E., Sala, L., Oostwaard, D. W. and Bellin, M.  Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome.  Biochemical And Biophysical Research Communications. 2021; 572, 118-124.  doi: 10.1016/j.bbrc.2021.07.068

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Marín Morales, J. M., Münch, N., Peter, K., Freund, D., Oelschlägel, U., Hölig, K., Böhm, T., Flach, A., Keßler, J., Bonifacio, E., Bornhäuser, M., Fuchs, A.  Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System. Frontiers In Immunology. 2019; 10:38.  doi:10.3389/fimmu.2019.00038

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Fonseka, C. Y., Rao, D. A., Teslovich, N. C., Korsunsky, I., Hannes, S. K., Slowikowski, K., Gurish, M. F., Donlin, L. T., Lederer, J. A., Weinblatt, M. E., Massarotti, E. M., Coblyn, J. S., Helfgott, S. M., Todd, D. J., Bykerk, V. P., Karlson, E. W., Ermann, J., Lee, Y. C., Brenner, M. B., Raychaudhuri, S. Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis. Science Translational Medicine. 2018; 10(463), eaaq0305. doi:10.1126/scitranslmed.aaq0305

Kuo-Jen Wu, Seong-Jin Yu, Chia-Wen Chiang, Yu-Wei Lee, B Linju Yen, Pei-Chi Tseng, Chun-Sen Hsu, Li-Wei Kuo, Yun Wang.  Neuroprotective Action of Human Wharton’s Jelly-Derived Mesenchymal Stromal Cell Transplants in a Rodent Model of Stroke.  Cell Transplant. 2018 Oct 4:963689718802754.  doi:10.1177/0963689718802754

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Sutton, M., Kaur, S., Brown, K., Skiles, M., Folz, M., Caplan, A., and Bonfield, T.  Anti-Inflammatory Therapeutic Development and Optimization of Umbilical Cord Tissue Derived Mesenchymal Stem Cells.  Journal Of Stem Cell Research & Therapy. 2018; 8(8), 1-9.  doi: 10.4172/2157-7633.1000435

Zhang, Z., Wilson, N. A., Chinnadurai, R., Panzer, S. E., Redfield, R. R., Reese, S. R., Galipeau, J., Djamali, A.  Autologous Mesenchymal Stromal Cells Prevent Transfusion-elicited Sensitization and Upregulate Transitional and Regulatory B Cells. Transplantation Direct. 2018 Sep; 4(9): e387.  doi:10.1097/txd.0000000000000827

Andriolo, G., Provasi, E., Lo Cicero, V., Brambilla, A., Soncin, S., Torre, T., Milano, G., Biemmi, V., Vassalli, G., Turchetto, L., Barile, L. and Radrizzani, M.  Exosomes From Human Cardiac Progenitor Cells for Therapeutic Applications: Development of a GMP-Grade Manufacturing Method.  Front. Physiol. 2018; 9:1169.  doi:10.3389/fphys.2018.01169

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Hamilton, C. A., Young, R., Jayaraman, S., Sehgal, A., Paxton, E., Thomson, S., Katzer, F., Hope, J., Innes, E., Morrison, L. J. and Mabbott, N. A.  Development of in vitro enteroids derived from bovine small intestinal crypts.  Veterinary Research. 2018; 49(1).  doi:10.1186/s13567-018-0547-5

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Aijaz, A., Li, M., Smith, D., Khong, D., LeBlon, C., Fenton, O. S., Olabisi, R. M., Libutti, S., Tischfield, J., Maus, M. V., Deans, R., Barcia, R. N., Anderson, D. G., Ritz, J., Preti, R., Parekkadan, B. Biomanufacturing for clinically advanced cell therapies.  Nature Biomedical Engineering 2018; 2(6), 362-376. doi:10.1038/s41551-018-0246-6

Pham, H., Tonai, R., Wu, M., Birtolo, C., Chen, M.  CD73, CD90, CD105 and Cadherin-11 RT-PCR Screening for Mesenchymal Stem Cells from Cryopreserved Human Cord Tissue.   Int. J. Stem Cells 2018; 11(1): 26-38.  doi:10.15283/ijsc17015

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Fernandopulle, M., Prestil, R., Grunseich, C., Wang, C., Gan, L., Ward, M. Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Current Protocols In Cell Biology 2018; 79(1), e51. doi:10.1002/cpcb.51

Lacher, M. D., Bauer, G., Fury, B., Graeve, S., Fledderman, E. L., Petrie, T. D., Coleal-Bergum, D. P., Hackett, T., Perotti, N. H., Kong, Y. Y., Kwok, W. W., Wagner, J. P., Wiseman, C. L., Williams, W. V. SV-BR-1-GM, A Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses An Immune Signature And Directly Activates CD4+ T Lymphocytes. Frontiers In Immunology 2018; 9(776), 1-23. doi:10.3389/fimmu.2018.00776

Lou Juliano, George Eastwood, Todd Berard, Aby J. Mathew. The Importance of Collection, Processing and Biopreservation Best Practices in Determining CAR-T Starting Material Quality. Cell Gene Therapy Insights 2018; 4(4), 327-336. doi: 10.18609/cgti.2018.032

Hiraishi, S., Schol, J., Sakai, D., Nukaga, T., Erickson, I., Silverman, L., Foley, K., Watanabe, M. Discogenic cell transplantation directly from a cryopreserved state in an induced intervertebral disc degeneration canine model. JOR Spine. (2018); 1(2), e1013. doi:10.1002/jsp2.1013

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Hung, C., Xu, X., Li, L., Ma, Y., Jin, Q., Viley, A., Allen, C., Natarajan, P., Shivakumar, R., Peshwa, M. V. and Emens, L. A. Development of Anti-Human Mesothelin-Targeted Chimeric Antigen Receptor Messenger RNA–Transfected Peripheral Blood Lymphocytes for Ovarian Cancer Therapy. Human Gene Therapy. 2018; 29(5), 614-625. doi:10.1089/hum.2017.080

Habiel, D., Espindola, M., Coelho, A., & Hogaboam, C. Modeling Idiopathic Pulmonary Fibrosis in Humanized SCID Mice. The American Journal of Pathology 2018 Apr; 188(4): 891-903. doi: 10.1016/j.ajpath.2017.12.020

Yongshun Lin, Huimin Liu, Michael Klein, John Ostrominski, So Gun Hong, Ravi Chandra Yada, Guibin Chen, Keron Navarengom, Robin Schwartzbeck, Hong San, Zu-Xi Yu, Chengyu Liu, Kaari Linask, Jeanette Beers, Lugui Qiu, Cynthia E. Dunbar, Manfred Boehm, Jizhong Zou. Efficient differentiation of cardiomyocytes and generation of calcium-sensor reporter lines from nonhuman primate iPSCs. Scientific Reports 2018 Vol. 8(1): 1-16. doi:10.1038/s41598-018-24074-y

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Brown, Zhou, McIntosh, Norman, Lou, Biermann, Sullivan, Kamp, Thomson, Anagnostopoulos, Burlingham. A Humanized Mouse Model Generated Using Surplus Neonatal Tissue. Stem Cell Reports (2018). doi:10.1016/j.stemcr.2018.02.011

Rouzbeh R. Taghizadeh, Kyle J. Cetrulo, Curtis L. Cetrulo. Collagenase Impacts the Quantity and Quality of Native Mesenchymal Stem/Stromal Cells Derived during Processing of Umbilical Cord Tissue. Cell Transplantation 2018, Vol. 27(1), 181–193. doi: 10.1177/0963689717744787

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Ivanics, Bergquist, Liu, Kim, Kang, Katz, Rios Perez, Thomas, Fleming, Truty. Patient-derived xenograft cryopreservation and reanimation outcomes are dependent on cryoprotectant type. Laboratory Investigation (2018). doi:10.1038/s41374-018-0042-7

Baradez, M., Biziato, D., Hassan, E., Marshall, D.  Application of Raman Spectroscopy and Univariate Modelling As a Process Analytical Technology for Cell Therapy Bioprocessing. Front. Med. 2018; 5(47), 1-14. doi:10.3389/fmed.2018.00047

Hardin, Vreeland, Clifton, Hale, Herbert, Greene, Jackson, Berry, Nichols, Yin, Yu, Wagner, Peoples. Tumor lysate particle loaded dendritic cell vaccine: preclinical testing of a novel personalized cancer vaccine. Immunotherapy (2018) 10(5), 373–382. https://doi.org/10.2217/imt-2017-0114

Mattar, M., McCarthy, C. R., Kulick, A. R., Qeriqi, B., Guzman, S., de Stanchina, E. Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models. Frontiers in Oncology 2018, 8 (Article 19): 1-18. doi:10.3389/fonc.2018.00019

Sampath, Won, Massarelli, Li, Frankel, Vora, Maghami, Kortylewski. Combined modality radiation therapy promotes tolerogenic myeloid cell populations and STAT3-related gene expression in head and neck cancer patients. Oncotarget, 2018, Vol. 9, (No. 13), pp: 11279-11290 . https://doi.org/10.18632/oncotarget.24397

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Griffiths, Habiel, Jaffar, Binder, Darby, Hosking, Skerra, Westall, Hogaboam, Foley. Anti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis. Scientific Reports (2018) 8:3212. DOI:10.1038/s41598-018-20811-5

Henrieta Fraser, Niloufar Safinia ,Nathali Grageda, Sarah Thirkell, Katie Lowe, Laura J. Fry, Cristiano Scottá, Andrew Hope, Christopher Fisher, Rachel Hilton, David Game, Paul Harden, Andrew Bushell, Kathryn Wood, Robert I. Lechler, Giovanna Lombardi.  A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials.  Molecular Therapy: Methods & Clinical Development 2018 March; 3:198-209.  doi: 10.1016/j.omtm.2018.01.006

Willie Lin, Yogi Chang-Yo Hsuan, Mao-Tsun Lin, Ting-Wei Kuo, Cheng-Hsien Lin, Yu-Chin Su, Ko-Chi Niu, Ching-Ping Chang, Hung-Jung Lin. Human Umbilical Cord Mesenchymal Stem Cells Preserve Adult Newborn Neurons and Reduce Neurological Injury after Cerebral Ischemia by Reducing the Number of Hypertrophic Microglia/Macrophages.  Cell Transplantation 2017 Nov; 26(11): 1798–1810. doi: 10.1177/0963689717728936

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Skiles, M., Brown, K., Tatz, W., Swingle, K., & Brown, H. Quantitative analysis of composite umbilical cord tissue health using a standardized explant approach and an assay of metabolic activity. Cytotherapy 2018, 20(4), 564-575. https://doi.org/10.1016/j.jcyt.2018.01.001

Petersen, Hassan, Morris, Jeffery, Lee, Jagirdar, Staton, Raikar, Spencer, Sulchek, Flowers, Waller. Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists. Blood Advances 2018 2:210-223. DOI 10.1182/bloodadvances.2017011254

Zheng, Hu, Wolfe, Gonsalves, Ren, Khawli, Kaslow, Epstein. Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti Tumor Effects against B-Cell Lymphoma. Int. J. Mol. Sci. 2017, 18, 2773. doi:10.3390/ijms18122773

Abazari A, Hawkins BJ, Clarke DM, Mathew AJ. Biopreservation Best Practices: A Cornerstone in the Supply Chain of Cell-based Therapies – MSC Model Case Study.  Cell Gene Therapy Insights 2017; 3(10), 853-871. DOI: 10.18609/cgti.2017.082

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Liao, Choi, Vojnits, Xue, Aroom, Meng, Pan, Hetz, Corkins, Hughes, Triolo, Johnson, Moise, Lally, Cox, Li. Tissue Engineering to Repair Diaphragmatic Defect in a Rat Model. Stem Cells International Volume 2017, Article ID 1764523, 12 pages. https://doi.org/10.1155/2017/1764523.

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Dustin R. Wakeman, Benjamin M. Hiller, David J. Marmion, Christopher W. McMahon, Grant T. Corbett, Kile P. Mangan, Junyi Ma, Lauren E. Little, Zhong Xie, Tamara Perez-Rosello, Jaime N. Guzman, D. James Surmeier, and Jeffrey H. Kordower. Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo. Stem Cell Reports j Vol. 9 j 1–13 j July 11, 2017. https://dx.doi.org/10.1016/j.stemcr.2017.04.033

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