HypoThermosol® for Hair Restoration

Advances in Hair Transplant Procedures

Due to the pioneering work of Dr. Jerry Cooley M.D. in demonstrating the benefits of HypoThermosol for ex-vivo graft storage, HypoThermosol is increasingly being adopted by leading hair restoration professionals. Anecdotal feedback from these thought leaders include improved engraftment of follicles and reduced edema.


There are many factors that contribute to the final quality of a hair transplant procedure. Hair transplant surgeons strive to control factors such as hydration, temperature, time out of body, and gentle handling of the transplant material. Once these basic factors have been accounted for, further improvements can be found only through addressing secondary factors such as operating techniques, graft care, storage solutions, and additives.


The Importance of Storage Media in Hair Transplant Procedures

Avram, M., Finney, R., Rogers, N.  Hair Transplantation Controversies.  Dermatologic Surgery. 2017; 43, S158-S162.  doi:10.1097/dss.0000000000001316

Castro, A. R., Portinha, C., Logarinho, E.  Impact of Preservation Solutions on the Trichogenicity of Hair Micrografts Ascertained by Dermal Papilla Gene Expression.  doi:10.1097/dss.0000000000001895

Kayiran O. Evolution of Hair Transplantation. Clinics in Surgery Article; Department Plastic and Reconstructive Surgery Clinic, Ankara Research and Training Hospital, Turkey

Mathew AJ. A review of cellular biopreservation considerations during hair transplantation. Hair Transplant Forum International, 2013; 23(1):1-11.

Rose, P. T., Nusbaum, A. G., Nusbaum, B. P. and Morgan, M. B.  A Comparison of Apoptotic Activity for Follicular Unit Extraction Hair Grafts Stored in Different Holding Solutions.  Dermatologic Surgery. 2019;00:1-3.  doi: 10.1097/dss.0000000000001977

Rose PT. Hair restoration surgery: challenges and solutions. Clinical, Cosmetic and Investigational Dermatology. 2015; 8: 361-370. Published online 2015 Jul 15. doi: 10.2147/CCID.S53980

Cooley, J. Ischemia-Reperfusion Injury and Graft Storage Solutions. Hair Transplant Forum International Volume 14, Number 4

Cooley, J. Bio-Enhanced Hair Restoration. Hair Transplant Forum International Volume 24, Number 4

See why HypoThermosol is quickly becoming the leading graft holding solution among hair restoration professionals.

Of the remaining factors that can be addressed to improve the quality of a hair transplant procedure; ex vivo storage of follicular units prior to implantation is perhaps the most important. Hair transplant grafts are subjected to a series of stresses from the time they are removed from the body until revascularization is complete approximately 3 days post operation. Dehydration, mechanical trauma, hypoxia, ATP depletion, reperfusion injury, cold injury and lactic acid accumulation are all pitfalls that serve to reduce viability of the follicular graft.

HypoThermosol® storage solution is an optimized storage solution that has been shown to increase the viability of hair grafts following a period of ex vivo storage. HypoThermosol is used by some of the worlds leading hair transplant surgeons to address a critical point during hair transplant surgery and improve the viability of grafts, and follicular units prior to implantation.

HypoThermosol is formulated specifically to support tissue samples during hypothermic storage, and address the stresses of hypothermia with balanced ions and molecules, targeted pH buffering, and potent free radical scavengers that reduce hair follicle cell death via apoptosis and necrosis.

  • Pre-Formulated
  • Serum-Free
  • Protein-Free
  • USP/Highest Quality Components
  • Sterility, Endotoxin, and Cell-Based Release Testing
  • Manufactured in compliance with FDA cGMP guidelines

Questions about how to incorporate HypoThermosol into your transplant procedure? Please contact us at info@biolifesolutions.com.

Call for special quantity discount pricing!

1 866 424 6543

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