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Home/Blog/Tag: “preclinical”

Tag: preclinical

Clinical-grade stem cell–derived retinal pigment epithelium patch rescues retinal degeneration in rodents and pigs

Sharma, R., Khristov, V., Rising, A., Jha, B. S., Dejene, R., Hotaling, N., Li, Y., Stoddard, J., Stankewicz, C., Wan, Q., Zhang, C., Campos, M. M., Miyagishima, K. J., McGaughey, D., Villasmil, R., Mattapallil, M., Stanzel, B., Qian, H., Wong, W., Chase, L., Charles, S., McGill, T., Miller, S., Maminishkis, A., Amaral, J., Bharti, K.…

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Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells

Mitsunaga, S., Shioda, K., Isselbacher, K. J., Hanna, J. H., Shioda, T.  Generation of Human Primordial Germ Cell-like Cells at the Surface of Embryoid Bodies from Primed-pluripotency Induced Pluripotent Stem Cells.  J. Vis. Exp. 2019; (143), e58297.  doi:10.3791/58297 (2019).

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Scale-up of a perfusion-based dendritic cell generation process

Kozbial, A., Weinstein, H., Murthy, S. K., Rossi, J. M.  Scale-up of a perfusion-based dendritic cell generation process.  Cell Gene Therapy Insights 2018; 4(11), 1117-1130.  doi: 10.18609/cgti.2018.110

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Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells

Murad, J. P., Kozlowska, A. K., Lee, H. J., Ramamurthy, M., Chang, W., Yazaki, P., Colcher, D., Shively, J., Cristea, M., Forman, S. J., Priceman, S. J.  Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells.  Front. Immunol. 2018; 9:2268.  doi:10.3389/fimmu.2018.02268

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In Vitro And In Vivo Evaluation Of Possible Pro-Survival Activities Of PGE2, EGF, TPO And FLT3L On Human Hematopoiesis

Demmerath, E., Bohler, S., Kunze, M., Erlacher, M.  In Vitro And In Vivo Evaluation Of Possible Pro-Survival Activities Of PGE2, EGF, TPO And FLT3L On Human Hematopoiesis.  Haematologica. November 2018; haematol.2018.191569.  doi:10.3324/haematol.2018.191569

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Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis

Fonseka, C. Y., Rao, D. A., Teslovich, N. C., Korsunsky, I., Hannes, S. K., Slowikowski, K., Gurish, M. F., Donlin, L. T., Lederer, J. A., Weinblatt, M. E., Massarotti, E. M., Coblyn, J. S., Helfgott, S. M., Todd, D. J., Bykerk, V. P., Karlson, E. W., Ermann, J., Lee, Y. C., Brenner, M. B., Raychaudhuri,…

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Neuroprotective Action of Human Wharton’s Jelly-Derived Mesenchymal Stromal Cell Transplants in a Rodent Model of Stroke

Kuo-Jen Wu, Seong-Jin Yu, Chia-Wen Chiang, Yu-Wei Lee, B Linju Yen, Pei-Chi Tseng, Chun-Sen Hsu, Li-Wei Kuo, Yun Wang.  Neuroprotective Action of Human Wharton’s Jelly-Derived Mesenchymal Stromal Cell Transplants in a Rodent Model of Stroke.  Cell Transplant. 2018 Oct 4:963689718802754.  doi:10.1177/0963689718802754

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Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing

Harrison, R., Lugo Leija, H. A., Strohbuecker, S., Crutchley, J., Marsh, S., Denning, C., El Haj, A., Sottile, V.  Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing.   Stem Cell Res Ther, 2018 Sept 26; 9(1):248.  doi:10.1186/s13287-018-0968-0.

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Anti-Inflammatory Therapeutic Development and Optimization of Umbilical Cord Tissue Derived Mesenchymal Stem Cells

Sutton, M., Kaur, S., Brown, K., Skiles, M., Folz, M., Caplan, A., and Bonfield, T.  Anti-Inflammatory Therapeutic Development and Optimization of Umbilical Cord Tissue Derived Mesenchymal Stem Cells.  Journal Of Stem Cell Research & Therapy. 2018; 8(8), 1-9.  doi: 10.4172/2157-7633.1000435

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Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells

Jin, J., Tarrant, R. D., Bolam, E. J., Angell-Manning, P., Soegaard, M., Pattinson, D. J., Dulal, P., Silk, S. E., Marshall, J. M., Dabbs, R. A., Nugent, F. L., Barrett, J. R., Hjerrild, K. A., Poulsen, L., Jørgensen, T., Brenner, T., Baleanu, I. N., Parracho, H. M., Tahiri-Alaoui, A., Whale, G., Moyle, S., Payne, R.…

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