Santeramo, I., Bagnati, M., Harvey, E.J., Hassan, E., Surmacz-Cordle, B., Marshall, D., Di Cerbo, V. Vector copy distribution at a single cell level enhances analytical characterisation of gene-modified cell therapies. Molecular Therapy – Methods & Clinical Development. 2020; 17, 944-956. doi: 10.1016/j.omtm.2020.04.016.
Read MoreMotwani, K., Peters, L. D., Vliegen, W. H., El-sayed, A. G., Seay, H. R., Lopez, M. C., Baker, H. V., Posgai, A. L., Brusko, M. A., Perry, D. J., Bacher, R., Larkin, J., Haller, M. J. and Brusko, T. M. Human Regulatory T Cells From Umbilical Cord Blood Display Increased Repertoire Diversity and Lineage Stability…
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Cryopreservation adds flexibility to timelines when working with cells. In the case of cellular therapies, that can mean initial flexibility to schedule patient cell collection, transport cells to the manufacturing facility and initiate manufacturing. Cryopreservation of the final cell therapy product adds flexibility to be able to schedule the return of cells to the patient…
Read MoreHanna, S. J., Powell, W. E., Long, A. E., Robinson, E. J. S., Davies, J., Megson, C., Howell, A., Jones, T. J., Ladell, K., Price, D. A., Dayan, C. M., Williams, A. J. K., Gillespie, K. M. and Wong, F. S. Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet…
Read MoreLam, N., Trinklein, N., Buelow, B., Patterson, G., Ojha, N., Kochenderfer, J. Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains. Nature Communications. 2020; 11(1). doi: 10.1038/s41467-019-14119-9
Read MoreMadissoon, E., Wilbrey-Clark, A., Miragaia, R. J., Saeb-Parsy, K., Mahbubani, K. T., Georgakopoulos, N., Harding, P., Polanski, K., Huang, N., Nowicki-Osuch, K., Fitzgerald, R. C., Loudon, K. W., Ferdinand, J. R., Clatworthy, M. R., Tsingene, A., van Dongen, S., Dabrowska, M., Patel, M., Stubbington, M. J. T., Teichmann, S. A., Stegle, O. and Meyer, K.…
Read MoreErkes, D. A., Cai, W., Sanchez, I. M., Purwin, T. J., Rogers, C., Field, C. O., Berger, A. C., Hartsough, E. J., Rodeck, U., Alnemri, E. S. and Aplin, A. E. Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis. Cancer Discovery. 2019; 10(2), 254-269. doi: 10.1158/2159-8290.cd-19-0672
Read MoreFedorova, L., Mudry, P., Pilatova, K., Selingerova, I., Merhautova, J., Rehak, Z., Valik, D., Hlavackova, E., Cerna, D., Faberova, L., Mazanek, P., Pavelka, Z., Demlova, R., Sterba, J., Zdrazilova-Dubska, L. Assessment of Immune Response Following Dendritic Cell-Based Immunotherapy in Pediatric Patients With Relapsing Sarcoma. Frontiers in Oncology. 2019; 9. doi:10.3389/fonc.2019.01169
Read MoreAbazari, A. Process development considerations for cryopreservation of cellular therapies. Cell & Gene Therapy Insights. 2019; 5(9), 1151–1167. doi: 10.18609/cgti.2019.122
Read MoreCurran, K. J., Margossian, S., Kernan, N. A., Silverman, L. B., Williams, D. A., Shukla, N. N., Kobos, R., Forlenza, C., Steinherz, P., Prockop, S., Boulad, F., Spitzer, B., Cancio, M. I., Boelens, J. J., Kung, A. L., Szenes, V. Z., Park, J., Sauter, C. S., Heller, G., Wang, X., Senechal, B., O’Reilly, R. J.,…
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