An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity

Carbonneau, S., Sharma, S., Peng, L., Rajan, V., Hainzl, D., Henault, M., Yang, C., Hale, J., Shulok, J., Tallarico, J., Porter, J., Brogdon, J., Dranoff, G., Bradner, J. E., Hild, M. and Guimaraes, C. P.  An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.  Cell Chemical Biology. 2020.  doi: 10.1016/j.chembiol.2020.11.012

Read More

Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data

Kerstan, A., Niebergall-Roth, E., Esterlechner, J., Schröder, H. M., Gasser, M., Waaga-Gasser, A. M., Goebeler, M., Rak, K., Schrüfer, P., Endres, S., Hagenbusch, P., Kraft, K., Dieter, K., Ballikaya, S., Stemler, N., Sadeghi, S., Tappenbeck, N., Murphy, G. F., Orgill, D. P., Frank, N. Y., Ganss, C., Scharffetter-Kochanek, K., Frank, M. H. and Kluth, M.…

Read More

Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy

Esser, L. K., Branchi, V., Leonardelli, S., Pelusi, N., Simon, A. G., Klümper, N., Ellinger, J., Hauser, S., Gonzalez-Carmona, M. A., Ritter, M., Kristiansen, G., Schorle, H., Hölzel, M. and Toma, M. I.  Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy.  Frontiers…

Read More

Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations

Konala, V. B. R., Nandakumar, S., Battu, R. and Pal, R.  Derivation of three induced pluripotent stem cell lines under feeder-free culture conditions from peripheral blood mononuclear cells (PBMC) of Indian patients suffering from inherited retinal diseases carrying different mutations.  Stem Cell Research. 2020; 45, 101757.  doi: 10.1016/j.scr.2020.101757

Read More