Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy

William McCoull, Scott Boyd, Martin R. Brown, Muireann Coen, Olga Collingwood, Nichola L. Davies, Ann Doherty, Gary Fairley, Kristin Goldberg, Elizabeth Hardaker, Guang He, Edward J. Hennessy, Philip Hopcroft, George Hodgson, Anne Jackson, Xiefeng Jiang, Ankur Karmokar, Anne-Laure Lainé, Nicola Lindsay, Yumeng Mao, Roshini Markandu, Lindsay McMurray, Neville McLean, Lorraine Mooney, Helen Musgrove, J. Willem…

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Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing

Nagarathinam Selvaraj, Chao-Kuei Wang, Brian Bowser, Trevor Broadt, Samir Shaban, Jenna Burns, Nirmala Saptharishi, Peter Pechan, Diane Golebiowski, Asaf Alimardanov, Nora Yang, George Mitra, and Ramarao Vepachedu.  Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.  Human Gene Therapy. 2021; 32(15-16), 850-861.  doi: 10.1089/hum.2020.054

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An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity

Carbonneau, S., Sharma, S., Peng, L., Rajan, V., Hainzl, D., Henault, M., Yang, C., Hale, J., Shulok, J., Tallarico, J., Porter, J., Brogdon, J., Dranoff, G., Bradner, J. E., Hild, M. and Guimaraes, C. P.  An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.  Cell Chemical Biology. 2020.  doi: 10.1016/j.chembiol.2020.11.012

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