Our library of independent research demonstrates the effectiveness of BioLife Solutions’ products.

Over 600 independent research projects show how BioLife Solutions products improve sample viability.

If you want to extend cell stability, improve cell viability, and lower the average cost per delivered dose of your cell therapy product, learn specifically how we can help your company ask one of our scientists directly.


Biopreserved in Home-Brew Media


Biopreserved in HypoThermosol
Biopreserved in Home-Brew Media
Biopreserved in HypoThermosol

Over 600 Articles, Abstracts and Posters Citing the Use of CryoStor and HypoThermosol.

Hundreds of articles have been written about the use of our products, CryoStor and HypoThermosol. Learn more about our products’ use in the cell and gene therapy industry, or ask one of our scientists a question directly.

Performance Evidence

Cryopreservation Freeze Media

Friedrich, M., Pohin, M., Jackson, M. A., Korsunsky, I., Bullers, S. J., Rue-Albrecht, K., Christoforidou, Z., Sathananthan, D., Thomas, T., Ravindran, R., Tandon, R., Peres, R. S., Sharpe, H., Wei, K., Watts, G. F. M., Mann, E. H., Geremia, A., Attar, M., Barone, F., Brenner, M., Buckley, C. D., Coles, M., Frei, A. P., Lassen, K. G., Powrie, F. M., McCuaig, S., Thomas, L., Collantes, E., Uhlig, H. H., Sansom, S. N., Easton, A., Raychaudhuri, S., Travis, S. P. and Powrie, F. M. IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies. Nature Medicine. 2021. doi: 10.1038/s41591-021-01520-5

Prakadan, S. M., Alvarez-Breckenridge, C. A., Markson, S. C., Kim, A. E., Klein, R. H., Nayyar, N., Navia, A. W., Kuter, B. M., Kolb, K. E., Bihun, I., Mora, J. L., Bertalan, M. S., Shaw, B., White, M., Kaplan, A., Stocking, J. H., Wadsworth, M. H., Lee, E. Q., Chukwueke, U., Wang, N., Subramanian, M., Rotem, D., Cahill, D. P., Adalsteinsson, V. A., Miller, J. W., Sullivan, R. J., Carter, S. L., Brastianos, P. K. and Shalek, A. K. Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases. Nature Communications. 2021; 12(1). doi: 10.1038/s41467-021-25860-5

Gee, S., Chandiramani, M., Seow, J., Pollock, E., Modestini, C., Das, A., Tree, T., Doores, K. J., Tribe, R. M. and Gibbons, D. L. The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate. Nature Immunology. 2021. doi: 10.1038/s41590-021-01049-2

Erol, O. D., Pervin, B., Seker, M. E. and Aerts-Kaya, F. Effects of storage media, supplements and cryopreservation methods on quality of stem cells. World Journal Of Stem Cells. 2021; 13(9), 1197-1214. doi: 10.4252/wjsc.v13.i9.1197

Palen, K., Zurko, J., Johnson, B. D., Hari, P. and Shah, N. N.  Manufacturing chimeric antigen receptor T cells from cryopreserved peripheral blood cells: time for a collect-and-freeze model?  Cytotherapy. 2021.  doi: 10.1016/j.jcyt.2021.07.015

Cho, H., Gonzales-Wartz, K. K., Huang, D., Yuan M., Peterson, M., Liang, J., Beutler, N., Torres, J. L., Cong, Y., Postnikova, E., Bangaru, S., Talana, C. A., Shi, W., Yang, E. S., Zhang, Y., Leung, K., Wang, L., Peng, L., Skinner, J., Li, S., Wu, N. C., Liu, H., Dacon, C., Moyer,T., Cohen, M., Zhao, M., Lee, F. E., Weinberg, R. S.,Douagi, I., Gross, R., Schmaljohn, C., Pegu, A., Mascola, J. R., Holbrook, M., Nemazee, D., Rogers, T. F.,Ward, A. B., Wilson, I. A., Crompton, P. D., Tan, J.  Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.  Sci. Transl. Med. 2021.  doi: 10.1126/scitranslmed.abj5413

Smith, D., Price, D. R. G., Burrells, A., Faber, M. N., Hildersley, K. A., Chintoan-Uta, C., Chapuis, A. F., Stevens, M., Stevenson, K., Burgess, S. T. G., Innes, E. A., Nisbet, A. J. and McNeilly, T. N.  The Development of Ovine Gastric and Intestinal Organoids for Studying Ruminant Host-Pathogen Interactions.  Frontiers In Cellular And Infection Microbiology. 2021; 11.  doi: 10.3389/fcimb.2021.733811

William McCoull, Scott Boyd, Martin R. Brown, Muireann Coen, Olga Collingwood, Nichola L. Davies, Ann Doherty, Gary Fairley, Kristin Goldberg, Elizabeth Hardaker, Guang He, Edward J. Hennessy, Philip Hopcroft, George Hodgson, Anne Jackson, Xiefeng Jiang, Ankur Karmokar, Anne-Laure Lainé, Nicola Lindsay, Yumeng Mao, Roshini Markandu, Lindsay McMurray, Neville McLean, Lorraine Mooney, Helen Musgrove, J. Willem M. Nissink, Alexander Pflug, Venkatesh Pilla Reddy, Philip B. Rawlins, Emma Rivers, Marianne Schimpl, Graham F. Smith, Sharon Tentarelli, Jon Travers, Robert I. Troup, Josephine Walton, Cheng Wang, Stephen Wilkinson, Beth Williamson, Jon Winter-Holt, Dejian Yang, Yuting Zheng, Qianxiu Zhu, and Paul D. Smith.  Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy.  Journal Of Medicinal Chemistry. 2021; Article ASAP.  doi: 10.1021/acs.jmedch

Schaniel, C., Papa, L., Meseck, M. L., Kintali, M., Djedaini, M., Zangui, M., Iancu-Rubin, C. and Hoffman, R.  Evaluation of a clinical-grade, cryopreserved, ex vivo-expanded stem cell product from cryopreserved primary umbilical cord blood demonstrates multilineage hematopoietic engraftment in mouse xenografts.  Cytotherapy. 2021; 23(9), 841-851.  doi: 10.1016/j.jcyt.2021.04.001

van der Walle, C.F., Godbert, S., Saito, G., Azhari, Z.  Formulation Considerations for Autologous T Cell Drug Products.  Pharmaceutics 2021; 13, 1317.  doi: 10.3390/pharmaceutics13081317

Bluhmki, T., Traub, S., Müller, A., Bitzer, S., Schruf, E., Bammert, M., Leist, M., Gantner, F., Garnett, J. P. and Heilker, R.  Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air–liquid interface model.  Scientific Reports. 2021; 11(1).  doi: 10.1038/s41598-021-96565-4

Nagarathinam Selvaraj, Chao-Kuei Wang, Brian Bowser, Trevor Broadt, Samir Shaban, Jenna Burns, Nirmala Saptharishi, Peter Pechan, Diane Golebiowski, Asaf Alimardanov, Nora Yang, George Mitra, and Ramarao Vepachedu.  Detailed Protocol for the Novel and Scalable Viral Vector Upstream Process for AAV Gene Therapy Manufacturing.  Human Gene Therapy. 2021; 32(15-16), 850-861.  doi: 10.1089/hum.2020.054

Dumas, P., Villacreces, A., Guitart, A. V., El-habhab, A., Massara, L., Mansier, O., Bidet, A., Martineau, D., Fernandez, S., Leguay, T., Pigneux, A., Vigon, I., Pasquet, J. and Desplat, V. Dual Inhibition of FLT3 and AXL by Gilteritinib Overcomes Hematopoietic Niche-Driven Resistance Mechanisms in FLT3-ITD Acute Myeloid Leukemia.  Clinical Cancer Research. 2021; 27:6012-25. doi: 10.1158/1078-0432.ccr-20-3114

Dumas, P., Villacreces, A., Guitart, A. V., Ali, E. H., Massara, L., Mansier, O., Bidet, A., Martineau, D., Fernandez, S., Leguay, T., Pigneux, A., Vigon, I., Pasquet, J. and Desplat, V.
Dual inhibition of FLT3 and AXL by gilteritinib overcomes hematopoietic niche-driven resistance mechanisms in FLT3-ITD acute myeloid leukemia.  Clinical Cancer Research. August 16 2021.  doi: 10.1158/1078-0432.ccr-20-3114

Tian E., Zhang M., and Shi Y. Direct Reprogramming of Fibroblasts to Astrocytes Using Small Molecules.  In: Ahlenius H. (eds) Neural Reprogramming. Methods in Molecular Biology. 2021; vol 2352, pp. 45-55. Humana, New York, NY.  doi: 10.1007/978-1-0716-1601-7_4

Quist E., Ahlenius H., and Canals I.  Transcription Factor Programming of Human Pluripotent Stem Cells to Functionally Mature Astrocytes for Monocultures and Cocultures with Neurons.  In: Ahlenius H. (eds) Neural Reprogramming. Methods in Molecular Biology. 2021; vol 2352, pp. 133-148. Humana, New York, NY.  doi: 10.1007/978-1-0716-1601-7_10

Deonaraine, K. K., Carlucci, P. M., Fava, A., Li, J., Wofsy, D., James, J. A., Putterman, C., Diamond, B., Davidson, A., Fine, D. M., Monroy-Trujillo, J., Atta, M. G., Haag, K., Rao, D. A., Apruzzese, W., Belmont, H. M., Izmirly, P. M., Wu, M., Connery, S., Payan-Schober, F., Furie, R. A., Berthier, C. C., Dall’Era, M., Cho, K., Kamen, D. L., Kalunian, K., Anolik, J., Ishimori, M., Weisman, M. H., Petri, M. A. and Buyon, J. P.  Safety of procuring research tissue during a clinically indicated kidney biopsy from patients with lupus: data from the Accelerating Medicines Partnership RA/SLE Network.  Lupus Science & Medicine. 2021; 8(1), e000522.  doi: 10.1136/lupus-2021-000522

Keddache, S., Laheurte, C., Boullerot, L., Laurent, L., Dalphin, J., Adotevi, O. and Soumagne, T.  Inflammatory and immunological profile in COPD secondary to organic dust exposure.  Clinical Immunology. 2021; 108798.  doi: 10.1016/j.clim.2021.108798

Giacomelli, E., Sala, L., Oostwaard, D. W. and Bellin, M.  Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome.  Biochemical And Biophysical Research Communications. 2021; 572, 118-124.  doi: 10.1016/j.bbrc.2021.07.068

Vitanza, N. A., Johnson, A. J., Wilson, A. L., Brown, C., Yokoyama, J. K., Künkele, A., Chang, C. A., Rawlings-Rhea, S., Huang, W., Seidel, K., Albert, C. M., Pinto, N., Gust, J., Finn, L. S., Ojemann, J. G., Wright, J., Orentas, R. J., Baldwin, M., Gardner, R. A., Jensen, M. C. and Park, J. R.  Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis.  Nature Medicine.  2021.  doi: 10.1038/s41591-021-01404-8

Gennert, D. G., Lynn, R. C., Granja, J. M., Weber, E. W., Mumbach, M. R., Zhao, Y., Duren, Z., Sotillo, E., Greenleaf, W. J., Wong, W. H., Satpathy, A. T., Mackall, C. L. and Chang, H. Y.  Dynamic chromatin regulatory landscape of human CAR T cell exhaustion.  Proceedings Of The National Academy Of Sciences. 2021; 118(30), e2104758118.  doi: 10.1073/pnas.2104758118

Reyes, M., Filbin, M. R., Bhattacharyya, R. P., Sonny, A., Mehta, A., Billman, K., Kays, K. R., Pinilla-Vera, M., Benson, M. E., Cosimi, L. A., Hung, D. T., Levy, B. D., Villani, A., Sade-Feldman, M., Baron, R. M., Goldberg, M. B., Blainey, P. C. and Hacohen, N.  Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.  Science Translational Medicine. 2021; 13(598), eabe9599.  doi: 10.1126/scitranslmed.abe9599

Larson, A. and Chin, M. T.  A method for cryopreservation and single nucleus RNA-sequencing of normal adult human interventricular septum heart tissue reveals cellular diversity and function.  BMC Medical Genomics. 2021; 14(1).  doi: 10.1186/s12920-021-01011-z

Soni, M., Migliori, E., Assal, A., Chan, H. T., Ciubotariu, R., Pan, J. B., Cicero, K., Pereira, M., Mapara, M. Y. and Muranski, P. Development of T-cell immunity in a liver and hematopoietic stem cell transplant recipient following coronavirus disease 2019 infection. Cytotherapy. 2021; 23(11), 980-984. doi: 10.1016/j.jcyt.2021.05.005

Wang, Y., Mohseni, M., Grauel, A., Diez, J. E., Guan, W., Liang, S., Choi, J. E., Pu, M., Chen, D., Laszewski, T., Schwartz, S., Gu, J., Mansur, L., Burks, T., Brodeur, L., Velazquez, R., Kovats, S., Pant, B., Buruzula, G., Deng, E., Chen, J. T., Sari-Sarraf, F., Dornelas, C., Varadarajan, M., Yu, H., Liu, C., Lim, J., Hao, H., Jiang, X., Malamas, A., LaMarche, M. J., Geyer, F. C., McLaughlin, M., Costa, C., Wagner, J., Ruddy, D., Jayaraman, P., Kirkpatrick, N. D., Zhang, P., Iartchouk, O., Aardalen, K., Cremasco, V., Dranoff, G., Engelman, J. A., Silver, S., Wang, H., Hastings, W. D. and Goldoni, S.  SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms.  Scientific Reports. 2021; 11(1). doi: 10.1038/s41598-021-80999-x.  doi: 10.1038/s41598-021-80999-x

Kusena, J. W. T., Shariatzadeh, M., Studd, A. J., James, J. R., Thomas, R. J. and Wilson, S. L.  The importance of cell culture parameter standardization: an assessment of the robustness of the 2102Ep reference cell line.  Bioengineered. 2021; 12(1), 341-357.  doi: 10.1080/21655979.2020.1870074

Yang, F., Patton, K., Kasprzyk, T., Long, B., Gupta, S., Zoog, S. J., Tracy, K. and Vettermann, C.  Validation of an IFN-gamma ELISpot assay to measure cellular immune responses against viral antigens in non-human primates.  Gene Therapy. 2021.  doi: 10.1038/s41434-020-00214-w

Fattorelli, N., Martinez-Muriana, A., Wolfs, L., Geric, I., De Strooper, B. and Mancuso, R.  Stem-cell-derived human microglia transplanted into mouse brain to study human disease.  Nature Protocols. 2021.  doi: 10.1038/s41596-020-00447-4

Lanzoni, G., Linetsky, E., Correa, D., Messinger Cayetano, S., Alvarez, R. A., Kouroupis, D., Alvarez Gil, A., Poggioli, R., Ruiz, P., Marttos, A. C., Hirani, K., Bell, C. A., Kusack, H., Rafkin, L., Baidal, D., Pastewski, A., Gawri, K., Leñero, C., Mantero, A. M. A., Metalonis, S. W., Wang, X., Roque, L., Masters, B., Kenyon, N. S., Ginzburg, E., Xu, X., Tan, J., Caplan, A. I., Glassberg, M. K., Alejandro, R. and Ricordi, C.  Umbilical cord mesenchymal stem cells for COVID ‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial.  STEM CELLS Translational Medicine. 2021.  doi: 10.1002/sctm.20-0472

Mazini, L., Ezzoubi, M. and Malka, G.  Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19.  Stem Cell Research & Therapy. 2021; 12(1).  doi: 10.1186/s13287-020-02006-w

Barbeau, S., Desprat, R., Eymard, B., Martinat, C., Lemaitre, J. and Legay, C.
Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ.  Stem Cell Research. 2020; 49, 102106.  doi: 10.1016/j.scr.2020.102106

Mogilenko, D. A., Shpynov, O., Andhey, P. S., Arthur, L., Swain, A., Esaulova, E., Brioschi, S., Shchukina, I., Kerndl, M., Bambouskova, M., Yao, Z., Laha, A., Zaitsev, K., Burdess, S., Gillfilan, S., Stewart, S. A., Colonna, M. and Artyomov, M. N.  Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging.  Immunity. 2020. doi: 10.1016/j.immuni.2020.11.005

Shim, J., Kim, K., Kim, K. G., Choi, U., Kyung, J. W., Sohn, S., Lim, S. H., Choi, H., Ahn, T., Choi, H. J., Shin, D. and Han, I.  Safety and efficacy of Wharton’s jelly‐derived mesenchymal stem cells with teriparatide for osteoporotic vertebral fractures: A phase I/IIa study.  STEM CELLS Translational Medicine. 2020.  doi: 10.1002/sctm.20-0308

Carbonneau, S., Sharma, S., Peng, L., Rajan, V., Hainzl, D., Henault, M., Yang, C., Hale, J., Shulok, J., Tallarico, J., Porter, J., Brogdon, J., Dranoff, G., Bradner, J. E., Hild, M. and Guimaraes, C. P.  An IMiD-inducible degron provides reversible regulation for chimeric antigen receptor expression and activity.  Cell Chemical Biology. 2020.  doi: 10.1016/j.chembiol.2020.11.012

Benitez, E. K., Lomova Kaufman, A., Cervantes, L., Clark, D. N., Ayoub, P. G., Senadheera, S., Osborne, K., Sanchez, J. M., Crisostomo, R. V., Wang, X., Reuven, N., Shaul, Y., Hollis, R. P., Romero, Z. and Kohn, D. B.  Global and Local Manipulation of DNA Repair Mechanisms to Alter Site-Specific Gene Editing Outcomes in Hematopoietic Stem Cells.  Frontiers In Genome Editing. 2020; 2:601541.  doi: 10.3389/fgeed.2020.601541

Roark, R. S., Li, H., Williams, W. B., Chug, H., Mason, R. D., Gorman, J., Wang, S., Lee, F., Rando, J., Bonsignori, M., Hwang, K., Saunders, K. O., Wiehe, K., Moody, M. A., Hraber, P. T., Wagh, K., Giorgi, E. E., Russell, R. M., Bibollet-Ruche, F., Liu, W., Connell, J., Smith, A. G., DeVoto, J., Murphy, A. I., Smith, J., Ding, W., Zhao, C., Chohan, N., Okumura, M., Rosario, C., Ding, Y., Lindemuth, E., Bauer, A. M., Bar, K. J., Ambrozak, D., Chao, C. W., Chuang, G., Geng, H., Lin, B. C., Louder, M. K., Nguyen, R., Zhang, B., Lewis, M. G., Raymond, D., Doria-Rose, N. A., Schramm, C. A., Douek, D. C., Roederer, M., Kepler, T. B., Kelsoe, G., Mascola, J. R., Kwong, P. D., Korber, B. T., Harrison, S. C., Haynes, B. F., Hahn, B. H. and Shaw, G. M.  Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.  Science. 2020; 371(6525), eabd2638.  doi: 10.1126/science.abd2638

Herzig MC, Delavan CP, Jensen KJ, Cantu C, Montgomery RK, Christy BA, Cap AP, Bynum JA.  A streamlined proliferation assay using mixed lymphocytes for evaluation of human mesenchymal stem cell immunomodulation activity.  J Immunol Methods. 2020 Nov 16:112915.  doi: 10.1016/j.jim.2020.112915

Mirizio, E., Tabib, T., Wang, X., Chen, W., Liu, C., Lafyatis, R., Jacobe, H. and Torok, K. S.  Single-cell transcriptome conservation in a comparative analysis of fresh and cryopreserved human skin tissue: pilot in localized scleroderma.  Arthritis Research & Therapy. 2020; 22(1).  doi: 10.1186/s13075-020-02343-4

Li, Y., Bouza, M., Wu, C., Guo, H., Huang, D., Doron, G., Temenoff, J. S., Stecenko, A. A., Wang, Z. L. and Fernández, F. M.  Sub-nanoliter metabolomics via mass spectrometry to characterize volume-limited samples.  Nature Communications. 2020; 11(1).  doi: 10.1038/s41467-020-19444-y

Todd CJ Berard, Aby J Mathew.  Biopreservation and cold chain biologistics risk points in the cell and gene therapy workflow.  Cell & Gene Therapy Insights 2020; 6(08), 1363–1380.  doi: 10.18609/cgti.2020.150

Beh, S. T., Frisch, C., Brafman, D. A., Churko, J., Walker, J. E., Serrano, G. E., Sue, L. I., Reiman, E. M., Beach, T. G. and Lue, L.   Human Autopsy-Derived Scalp Fibroblast Biobanking for Age-Related Neurodegenerative Disease Research.  Cells. 2020; 9(11), 2383.  doi: 10.3390/cells9112383

Sade, M., Reyes, M. and Chloe, A.  MGH COVID-19 Effort Blood Processing Protocol for PBMC, Neutrophils and Plasma Isolation.  protocols.io. 2020.  doi: 10.17504/protocols.io.bjhnkj5e

Klara Valyi-Nagy, Fay Betsou, Alexandru Susma, and Tibor Valyi-Nagy.  Optimization of Viable Glioblastoma Cryopreservation for Establishment of Primary Tumor Cell Cultures.  BIOPRESERVATION AND BIOBANKING.  doi: 10.1089/bio.2020.0050

Nguyen, L. T., Trieu, T. T. H., Bui, H. T. H., Hoang, V. T., Nguyen, A. T. T., Trinh, N. T. H., Nguyen, K. T. and Hoang, D. M.  Allogeneic administration of human umbilical cord-derived mesenchymal stem/stromal cells for bronchopulmonary dysplasia: preliminary outcomes in four Vietnamese infants.  Journal Of Translational Medicine. 2020; 18, 398.  doi: 10.1186/s12967-020-02568-6

Block, M. S., Dietz, A. B., Gustafson, M. P., Kalli, K. R., Erskine, C. L., Youssef, B., Vijay, G. V., Allred, J. B., Pavelko, K. D., Strausbauch, M. A., Lin, Y., Grudem, M. E., Jatoi, A., Klampe, C. M., Wahner-Hendrickson, A. E., Weroha, S. J., Glaser, G. E., Kumar, A., Langstraat, C. L., Solseth, M. L., Deeds, M. C., Knutson, K. L. and Cannon, M. J.  Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients.  Nature Communications.  2020; 11(1).  doi: 10.1038/s41467-020-18962-z

Menon, R., Otto, E. A., Sealfon, R., Nair, V., Wong, A. K., Theesfeld, C. L., Chen, X., Wang, Y., Boppana, A. S., Luo, J., Yang, Y., Kasson, P. M., Schaub, J. A., Berthier, C. C., Eddy, S., Lienczewski, C. C., Godfrey, B., Dagenais, S. L., Sohaney, R., Hartman, J., Fermin, D., Subramanian, L., Looker, H. C., Harder, J. L., Mariani, L. H., Hodgin, J. B., Sexton, J. Z., Wobus, C. E., Naik, A. S., Nelson, R. G., Troyanskaya, O. G. and Kretzler, M.  SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease.  Kidney International. 2020.  doi: 10.1016/j.kint.2020.09.015

Ha, C. W., Martin, A., Sepich-Poore, G. D., Shi, B., Wang, Y., Gouin, K., Humphrey, G., Sanders, K., Ratnayake, Y., Chan, K. S., Hendrick, G., Caldera, J., Arias, C., Moskowitz, J. E., Ho Sui, S. J., Yang, S., Underhill, D., Brady, M. J., Knott, S., Kaihara, K., Steinbaugh, M. J., Li, H., McGovern, D. P., Knight, R., Fleshner, P. and Devkota, S.  Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.  Cell. 2020.  doi: 10.1016/j.cell.2020.09.009

Noh, J., Oh, S., Park, I. and Song, J.  Intracerebral Transplants of GMP-Grade Human Umbilical Cord-Derived Mesenchymal Stromal Cells Effectively Treat Subacute-Phase Ischemic Stroke in a Rodent Model.  Frontiers In Cellular Neuroscience. 2020; 14.  doi: 10.3389/fncel.2020.546659

Wang, X., Karki, U., Abeygunaratne, H., UnnoldCofre, C. and Xu, J.  Plant cell-secreted stem cell factor stimulates expansion and differentiation of hematopoietic stem cells.  Process Biochemistry. 2021; 100, 39-48.  doi: 10.1016/j.procbio.2020.09.029

Esser, L. K., Branchi, V., Leonardelli, S., Pelusi, N., Simon, A. G., Klümper, N., Ellinger, J., Hauser, S., Gonzalez-Carmona, M. A., Ritter, M., Kristiansen, G., Schorle, H., Hölzel, M. and Toma, M. I.  Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy.  Frontiers In Oncology. 2020; 10.  doi: 10.3389/fonc.2020.01775

Penkava, F., Velasco-Herrera, M. D. C., Young, M. D., Yager, N., Nwosu, L. N., Pratt, A. G., Lara, A. L., Guzzo, C., Maroof, A., Mamanova, L., Cole, S., Efremova, M., Simone, D., Filer, A., Brown, C. C., Croxford, A. L., Isaacs, J. D., Teichmann, S., Bowness, P., Behjati, S. and Hussein Al-Mossawi, M.  Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis.  Nature Communications. 2020; 11(1).  doi: 10.1038/s41467-020-18513-6

Nguyen, H. T. L. and Soragni, A.  Patient-Derived Tumor Organoid Rings for Histologic Characterization and High-Throughput Screening.  STAR Protocols. 2020; 1: 22.  doi: 10.1016/j.xpro.2020.100056

Szabo, P., Wells, S., Sims, P. A., and Farber, D.  COVID Airway Processing for scRNAseq.  protocols.io.  doi: 10.17504/protocols.io.bjj8kkrw

Chandra, J., Woo, W. P., Finlayson, N., Liu, H. Y., McGrath, M., Ladwa, R., Brauer, M., Xu, Y., Hanson, S., Panizza, B., Frazer, I. H. and Porceddu, S. V.  A phase 1, single centre, open label, escalating dose study to assess the safety, tolerability and immunogenicity of a therapeutic human papillomavirus (HPV) DNA vaccine (AMV002) for HPV-associated head and neck cancer (HNC).  Cancer Immunology, Immunotherapy (2020).  doi: 10.1007/s00262-020-02720-7

Zhou, X., Li, H., Li, F., Song, X., Liu, T., Ma, T., Guo, H., Wu, N. and Li, J.  Generation and characterization of two iPSC lines from human adipose tissue-derived stem cells of healthy donors.  Stem Cell Research. 2020; 48, 101973.  doi: 10.1016/j.scr.2020.101973

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Valentine LE, Loffredo JT, Bean AT, León EJ, MacNair CE, Beal DR, Piaskowski SM, Klimentidis YC, Lank SM, Wiseman RW, Weinfurter JT, May GE, Rakasz EG, Wilson NA, Friedrich TC , O’Connor DH, Allison DB, Watkins DI. Infection with “Escaped” Virus Variants Impairs Control of Simian Immunodeficiency Virus SIVmac239. Journal of Virology, November 2009, p. 11514-11527, Vol. 83, No. 22. Copyright © 2009, American Society for Microbiology.

Clarke DM, Yadock DJ, Nicoud IB, Mathew AJ, Heimfeld S. Improved post-thaw recovery of peripheral blood stem/progenitor cells using a novel intracellular-like cryopreservation solution.  Cytotherapy. 2009;11(4):472-9. doi: 10.1080/14653240902887242.

Luckett-Chastain LR, Gallucci RM. Interleukin (IL)-6 Modulates Transforming Growth Factor-β Expression in Skin and Dermal Fibroblasts from IL-6-Deficient Mice. Br J Dermatol. 2009 August; 161(2): 237–248.

Chacon L, Gomez M, Jenkins J, Leibo S, Wirtu G, Dresser B, Pope C. Production of bovine cloned embryos with donor cells frozen at a slow cooling rate in a conventional freezer (−20 °C). Zygote: pp. 1-11. doi:10.1017/S0967199409005474

Güll I, Alves PM, Gabor F, Wirth M. Viability of the Human Adenocarcinoma Cell Line Caco-2: Influence of Cryoprotectant, Freezing Rate, and Storage Temperature. Sci Pharm. 2009; 77: 133–141.

Malpique R, Ehrhart F, Katsen-Globa A, Zimmermann H, Alves PM. Cryopreservation of Adherent Cells: Strategies to Improve Cell Viability and Function after Thawing. Tissue Engineering: Part C, Volume 15, Number 00, 2009.

Thirumala S, Goebel WS, Woods EJ. Clinical Grade Adult Stem Cell Banking. Organogenesis. 2009 Jul–Sep; 5(3): 143–154. © 2009 Landes Bioscience.

Woods EJ, et al. Optimized cryopreservation method for human dental pulp-derived stem cells and their tissues of origin for banking and clinical use. Cryobiology. 2009 Oct;59(2):150-7. DOI:10.1016/j.cryobiol.2009.06.005.

Perry BC, Zhou D, Wu X, Yang FC, Byers MA, Chu G, Hockema JJ, Woods EJ, Goebel WS. Collection, Cryopreservation, and Characterization of Human Dental Pulp–Derived Mesenchymal Stem Cells for Banking and Clinical Use. Tissue Engineering Part C: Methods. June 2008, 14(2): 149-156. doi:10.1089/ten.tec.2008.0031.

Ennis J, Sarugaser R, Gomez A, Baksh D, Davies JE. Isolation, Characterization, and Differentiation of Human Umbilical Cord Perivascular Cells (HUCPVCs). Methods in Cell Biology. 2008; Vol. 86, 121-136.

Baust, J. M., Vogel, M. J., Snyder, K. K., Van Buskirk, R. G., Baust, J. G.  Activation of Mitochondrial-Associated Apoptosis Contributes to Cryopreservation Failure.  Cell Preservation Technology. November 2007; 5(3).  doi:10.1089/cpt.2007.9990

Baust JM and Baust JG (2007) A Paradigm Shift in Cryopreservation: Molecular-Based Advances to Improve Outcome. In Klaus D Timmerhaus and Richard Reed (Eds.), CryoGenic Engineering; Fifty Years of Progress. XII, P. 374  © Springer Science+Business Media, LLC,  New York 2007

Mathew, AJ, Snyder, KK, Baust, JM. Methods for the Effective Preservation of Cell and Tissue Samples. BioTechniques Dec 2006; p.27

Van Buskirk RG, Snyder KK, Mathew AJ, Baust JG, Baust JM. Navigating the Postpreservation Viability Fog. (2006). GEN. Nov 1, 2006 (Vol. 26, No. 19)

Baust JM, Snyder KK, Mathew, AJ, Van Buskirk RG., Baust, John G. Steps to Improving Cryopreservation Outcome: Understanding key factors influencing efficacy.Bioscience Technology (2006)

Corning. Enhanced Survival of LNCaP Cells Following Cryopreservation Using the CryoStor™ CS5 Preservation Solution and Corning® CellBIND® Surface (2006)

Stylianou J, Vowels M, Hadfield K. Novel Cryoprotectant Significantly Improves the Post-thaw Recovery and Quality of HSC from CB. Cytotherapy, 8(Suppl 1):57. (2006).

Robilotto AT, Baust JM, Van Buskirk R, Baust JG. Involvement of the cysteine protease calpain family in the cell death following cryopreservation. Cell Preservation Technology 4(1) 2006.

Baust JM. Advances in Media for Cryopreservation and Hypothermic Storage. BioProcess International Supplement June: 46-56 (2005).

Van Buskirk RG, Snyder KK, Baust JG, Mathew AJ, Baust JM. Cryopreservation – It’s Not Just About Cell Yield. BioProcessing International,  April (2005).

Sosef MN, Baust JM, Sugimachi K., Fowler A, Tompkins RG, Toner M. Cryopreservation of isolated primary rat hepatocytes: enhanced survival and long-term hepatospecific function. Ann Surgery 241(1):125-33 (2005).

Snyder KK, Van Buskirk RG, Mathew AJ, Baust JG, Baust JM. Biological Packaging for the Global Cell and Tissue Therapy Markets. BioProcessing Journal May/June: 39-46 (2004).

Cho JJ, Joseph B, Sappal BS, Giri RK, Wang R, Ludlow JW, Furth ME, Susick R, Gupta S. Analysis of the functional integrity of cryopreserved human liver cells including xenografting in immunodeficient mice to address suitability for clinical applications. Liver Int. 24(4):361-70 (2004).

Sugimachi K., Sosef MN, Baust JM, Fowler A, Tompkins RG, Toner M. Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System. Cell Transplantation 13: 187-195 (2004).

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Baust JM, Van Buskirk RG, Baust JG. Gene activation of the apoptotic caspase cascade following cryogenic storage. Cell Preservation Technology 1(1): 63-80 (2002)

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Fink J, Abazari A, Hawkins B, Albert M, O’Donnell K, Mathew A. Best Practices vs. Traditional Practices of Procedures and Technology for Preserving Viability and Functionality of T-Cells at Both -80 C and -190 C. Biopreservation and Biobanking Volume 15, Number 3, 2017. DOI:10.1089=bio.2017.29021.abstracts

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Yasuhara T, Matsukawa N, Hara K, Maki M, Ali MM, Yu SJ, Bae E, Yu G, Xu L, McGrogan M, Bankiewicz K, Case C, Borlongan CV. Notch-Induced Rat and Human Bone Marrow Stromal Cell Grafts Reduce Ischemic Cell Loss and Ameliorate Behavioral Deficits in Chronic Stroke Animals. Stem Cells and Development. December 2009, 18(10): 1501-1514. doi:10.1089/scd.2009.0011.

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The Impact of feeding regimen and cell cycle on post-thaw recovery in a human T-cell model

Process Optimization for CD3+ T-Cell Formulation and Cryopreservation

Freezing Media Comparison Study Using CryoStor® CS10

The Effect of Cryomedia Selection and Transient Warming Events on Post-Cryopreservation Human MSC Function

Delineating the Critical Process Parameters for Cell Therapy Cryopreservation

Exploration of Shipping Conditions to Retain Viable Recovery for Umbilical Tissue

A Practical Method for Remote Collection and Preservation of Umbilical Cord Tissue

Cryopreservation and Transport of Jurkat T Cells Using Current and Optimized Practices: The Impact of Temperature and Length of Storage



Determination of an Optimal Formulation for CAR T-Cells: Cryopreservation Studies using Model T-Cells



Influencing Differentiation and Growth of Neural Progenitor Cells With Gene Silencing and Laminin

Cryopreservation of Apheresis Platelets Collected Using the Amicus Separator and Stored in the Collection Chamber


Continued Outgrowth of Cord Tissue-Derived Cells Over Multiple Platings From Cord Tissue Cryopreserved as a Composite Material


Scalable Xeno-Free Expansion of Human Mesenchymal Stromal Cells in a Single-Use, Vertical-Wheel Bioreactor System

Next Generation Technology Procedures and Products Facilitate Biopreservation Best Practices and Increased Viability for Cellular Therapy


Off the shelf cellular therapeutics: Factors to consider during cryopreservation and storage of human cells for clinical use.


Technology Transfer and Process Development for an Autologous Cell Therapy Against Multiple Sclerosis

Pub_2-Maxey_CLT-008_2014Immuno-Protective and Immuno-Suppressive Behavior Displayed by a Novel Viable Cell Bone Matrix


Pub_2-Maxey_CLT-008_2014Development of a Mouse Myeloid Progenitor Cell Therapeutic for Treatment of HS-ARS in BALB/c mice


Identification of CD73, CD90 and CD105 by qPCR in Cryopreserved Human Cord Tissue

Scalability of Allogeneic Stem Cell Manufacturing

Development of a quantitative measurement of mesenchymal stem cells explant outgrowth from umbilical cord tissue

Cryopreserved hMSCsmaintain comparable in vitro functional activity compared to fresh hMSCsISCT Poster FvT 052115 FINAL_roosterbio_icon

Cryopreserved Leukopaks Maintain Cell Viability and Functionality: A Solution for Cell Therapy LogisticsISCT Poster 2015_FINAL TCH HemaCare

Cryopreservation of donor lymphocyte clinical products with conventional 10% DMSO and CryoStor®2014 BEST 65 POSTER

GMP-Compliant Production Dendritic CellsPoster_Eyrich_ISCT2013_135

Reduced Engraftment Times using the PremierMaxCBSM Processing Methodology2013CBForum poster abicon

Cryopreservation Of CardiomyocytesIBET_cryopreservation of cardiomyocytes ECI_Page_1

Effect of Cryopreservation on Cell Viability, Recovery, and Proliferation

Stem Cell Cryopreservation Stability

Gel Improves Stability and Recovery

Cord Blood Stem Cell Banking Using CryoStorCord-Blood-Stem-Cell-Banking_thumb

Cryopreservation of Adherent Cells Using CryoStorMaximizing-Stability-of-Human-Stem-Cells.png

Cryopreservation Strategies of Adherent Cells

Improving Cryopreservation Yield

Safety Study of Intravenous Injection of Solutions

Accelerated Stability Study

Mitochondrial-Associated Pathway of Apoptosis Contributes to Failure

Cellular Proteomic Alterations Influence Cell Survival

Calpain Activation Contributes to Cell Death

Evolution of Biological Packaging and Biopreservation

Cryopreservation of Hepatocytes

Improved Stability Validation of Peripheral Blood Cell Products

Standardized Drug-Testing Using Tumor Samples

Considerations for cGMP Production of Patient-Specific Cell Therapeutics – A PACT Case Study. Derek JH. Webinar(slides). (2014).

Human-Derived Raw Materials: Controlled, Consistent Collections Enable Successful Manufacturing of Cell-Based Regenerative Medicine Products.

Combination of Biopreservation Solution and a Gel Component Improves Stability and Recovery of Cells.

New cryogenic container for clinical cryopreservation of biomaterials


Managing of a Stem Cell Biorepository

Hypothermic Storage & Shipping Media

Erol, O. D., Pervin, B., Seker, M. E. and Aerts-Kaya, F. Effects of storage media, supplements and cryopreservation methods on quality of stem cells. World Journal Of Stem Cells. 2021; 13(9), 1197-1214. doi: 10.4252/wjsc.v13.i9.1197

Ciervo, Y., Gatto, N., Allen, C., Grierson, A., Ferraiuolo, L., Mead, R. J. and Shaw, P. J. Adipose-derived stem cells protect motor neurons and reduce glial activation in both in vitro and in vivo models of ALS. Molecular Therapy – Methods & Clinical Development. 2021 Mar 27; 21:413-433. doi: 10.1016/j.omtm.2021.03.017

Ścieżyńska, A., Soszyńska, M., Szpak, P., Krześniak, N., Malejczyk, J. and Kalaszczyńska, I.  Influence of Hypothermic Storage Fluids on Mesenchymal Stem Cell Stability: A Comprehensive Review and Personal Experience.  Cells. 2021; 10(5), 1043.  doi: 10.3390/cells10051043

Nam, Y., Yoon, D., Hong, J., Kim, M. S., Lee, T. Y., Kim, K. S., Lee, H., Suk, K. and Kim, S. R. Therapeutic Effects of Human Mesenchymal Stem Cells in a Mouse Model of Cerebellar Ataxia with Neuroinflammation. Journal Of Clinical Medicine. 2021; 9(11), 3654. doi: 10.3390/jcm9113654

Todd CJ Berard, Aby J Mathew.  Biopreservation and cold chain biologistics risk points in the cell and gene therapy workflow.  Cell & Gene Therapy Insights 2020; 6(08), 1363–1380.  doi: 10.18609/cgti.2020.150

Singh, S., Chakravarty, T., Chen, P., Akhmerov, A., Falk, J., Friedman, O., Zaman, T., Ebinger, J. E., Gheorghiu, M., Marbán, L., Marbán, E. and Makkar, R. R.  Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series.  Basic Research In Cardiology. 2020; 115(4).  doi: 10.1007/s00395-020-0795-1

Mund, S. J. K., Kawamura, E., Awang-Junaidi, A. H., Campbell, J., Wobeser, B., MacPhee, D. J., Honaramooz, A. and Barber, S.  Homing and Engraftment of Intravenously Administered Equine Cord Blood-Derived Multipotent Mesenchymal Stromal Cells to Surgically Created Cutaneous Wound in Horses: A Pilot Project.  Cells. 2020; 9(5), 1162.  doi: 10.3390/cells9051162

Menon, R., Otto, E. A., Hoover, P. J., Eddy, S., Mariani, L. H., Godfrey, B., Berthier, C. C., Eichinger, F., Subramanian, L., Harder, J. L., Ju, W., Nair, V., Larkina, M., Naik, A. S., Luo, J., jain, S., Sealfon, R., Troyanskaya, O. G., Hacohen, N., Hodgin, J. B. and Kretzler, M.  Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker.  JCI Insight. 2020; 5(6):e133267.  doi:10.1172/jci.insight.133267

Madissoon, E., Wilbrey-Clark, A., Miragaia, R. J., Saeb-Parsy, K., Mahbubani, K. T., Georgakopoulos, N., Harding, P., Polanski, K., Huang, N., Nowicki-Osuch, K., Fitzgerald, R. C., Loudon, K. W., Ferdinand, J. R., Clatworthy, M. R., Tsingene, A., van Dongen, S., Dabrowska, M., Patel, M., Stubbington, M. J. T., Teichmann, S. A., Stegle, O. and Meyer, K. B.  scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation.  Genome Biology. 2020; 21(1).  doi: 10.1186/s13059-019-1906-x

Mata, M. F., Hernandez, D., Rologi, E., Grandolfo, D., Hassan, E., Hua, P., Kallmeier, R., Hirani, S., Heuts, F., Tittrea, V., Choo, Y., Baradez, M., Watt, S. M., Tarunina, M.  A modified CD34+ hematopoietic stem and progenitor cell isolation strategy from cryopreserved human umbilical cord blood.  Transfusion. 2019; 59(12), 3560-3569.  doi: 10.1111/trf.15597

Ruiz García, S., Deprez, M., Lebrigand, K., Cavard, A., Paquet, A., Arguel, M., Magnone, V., Truchi, M., Caballero, I., Leroy, S., Marquette, C., Marcet, B., Barbry, P., Zaragosi, L.  Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures.  Development. 2019; dev.177428.  doi:10.1242/dev.177428

Ursu, S., Majid, S., Garger, C., de Semir, D., Bezrookove, V., Desprez, P., McAllister, S., Soroceanu, L., Nosrati, M., Yimam, K., Hassoun, A., Osorio, R., Kashani-Sabet, M., Dar, A. A.  Novel tumor suppressor role of miRNA-876 in cholangiocarcinoma.  Oncogenesis. 2019; 8(8), 42.  doi:10.1038/s41389-019-0153-z

Rose, P. T., Nusbaum, A. G., Nusbaum, B. P. and Morgan, M. B.  A Comparison of Apoptotic Activity for Follicular Unit Extraction Hair Grafts Stored in Different Holding Solutions.  Dermatologic Surgery. 2020; 46(5): 721-723.  doi: 10.1097/dss.0000000000001977

Todorović, V., Su, Z., Putman, C. B., Kakavas, S. J., Salte, K. M., McDonald, H. A., Wetter, J. B., Paulsboe, S. E., Sun, Q., Gerstein, C. E., Medina, L., Sielaff, B., Sadhukhan, R., Stockmann, H., Richardson, P. L., Qiu, W., Argiriadi, M. A., Henry, R. F., Herold, J. M., Shotwell, J. B., McGaraughty, S. P., Honore, P., Gopalakrishnan, S. M., Sun, C. C., Scott, V. E.  Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis.  Scientific Reports. 2019; 9(1).  doi:10.1038/s41598-019-45626-w

Arazi, A., Rao, D. A., Berthier, C. C., Davidson, A., Liu, Y., Hoover, P. J., Chicoine, A., Eisenhaure, T. M., Jonsson, A. H., Li, S., Lieb, D. J., Zhang, F., Slowikowski, K., Browne, E. P., Noma, A., Sutherby, D., Steelman, S., Smilek, D. E., Tosta, P., Apruzzese, W., Massarotti, E., Dall’Era, M., Park, M., Kamen, D. L., Furie, R. A., Payan-Schober, F., Pendergraft, W. F., McInnis, E. A., Buyon, J. P., Petri, M. A., Putterman, C., Kalunian, K. C., Woodle, E. S., Lederer, J. A., Hildeman, D. A., Nusbaum, C., Raychaudhuri, S., Kretzler, M., Anolik, J. H., Brenner, M. B., Wofsy, D., Hacohen, N. and Diamond, B.  The immune cell landscape in kidneys of patients with lupus nephritis.  Nature Immunology. 2019; 20(7), 902-914.  doi:10.1038/s41590-019-0398-x

Ölander, M.  Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver.  Acta Universitatis Upsaliensis, Uppsala.  2019.  (PhD dissertation)

Wang, Y., Edelmayer, R., Wetter, J., Salte, K., Gauvin, D., Leys, L., Paulsboe, S., Su, Z., Weinberg, I., Namovic, M., Gauld, S. B., Honore, P., Scott, V. E., McGaraughty, S.  Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation.  Scientific Reports. 2019; 9: 5310.  doi:10.1038/s41598-019-41655-7

Read, E.  Qualification of cellular starting materials for cell-based therapies.  Cell & Gene Therapy Insights 2019; 5(2), 177-196.  doi: 10.18609/cgti.2019.021

Clarke, D., Smith, D.  Managing starting material stability to maximize manufacturing flexibility and downstream efficiency.  Cell & Gene Therapy Insights 2019; 5(2), 303-314.  doi: 10.18609/cgti.2019.033

Stroncek, D., Mathew, A., & McKenna, D. Cell therapies for trauma and critical care medicine: critical issues in translation for cellular and novel therapies in trauma and critical care. Transfusion. 2019; 59(S1), 854-857. doi:10.1111/trf.14832

Mathew, A. J.  Biopreservation Considerations for Regenerative Medicine GMP Manufacturing; 2018.  http://ebook.liebertpub.com/biolife-solutions/biopreservation-considerations-for-regenerative-medicine-gmp-manufacturing

Harrison, R., Lugo Leija, H. A., Strohbuecker, S., Crutchley, J., Marsh, S., Denning, C., El Haj, A., Sottile, V.  Development and validation of broad-spectrum magnetic particle labelling processes for cell therapy manufacturing.   Stem Cell Res Ther, 2018 Sept 26; 9(1):248.  doi:10.1186/s13287-018-0968-0.

Peltzer, J., Aletti, M., Frescaline, N., Busson, E., Lataillade, J. and Martinaud, C. Mesenchymal Stromal Cells Based Therapy in Systemic Sclerosis: Rational and Challenges. Front. Immunol. September 2018; 9:2013. doi:10.3389/fimmu.2018.02013

Barrachina, L., Romero, A., Zaragoza, P., Rodellar, C., Vázquez, F.  Practical considerations for clinical use of mesenchymal stem cells: From the laboratory to the horse.  The Veterinary Journal. 2018; 238, 49-57.  doi:10.1016/j.tvjl.2018.07.004

Lou Juliano, George Eastwood, Todd Berard, Aby J. Mathew. The Importance of Collection, Processing and Biopreservation Best Practices in Determining CAR-T Starting Material Quality. Cell Gene Therapy Insights 2018; 4(4), 327-336. doi: 10.18609/cgti.2018.032

Hiraishi, S., Schol, J., Sakai, D., Nukaga, T., Erickson, I., Silverman, L., Foley, K., Watanabe, M. Discogenic cell transplantation directly from a cryopreserved state in an induced intervertebral disc degeneration canine model. JOR Spine. (2018); 1(2), e1013. doi:10.1002/jsp2.1013

Mattar, M., McCarthy, C. R., Kulick, A. R., Qeriqi, B., Guzman, S., de Stanchina, E. Establishing and Maintaining an Extensive Library of Patient-Derived Xenograft Models Frontiers in Oncology 2018, 8 (Article 19): 1-18. doi:10.3389/fonc.2018.00019

Wang, Penland, Gokce, Croote, Quake. High fidelity hypothermic preservation of primary tissues in organ transplant preservative for single cell transcriptome analysis. BMC Genomics (2018) 19:140. https://doi.org/10.1186/s12864-018-4512-5

Abazari A, Hawkins BJ, Clarke DM, Mathew AJ. Biopreservation Best Practices: A Cornerstone in the Supply Chain of Cell-based Therapies – MSC Model Case Study.  Cell Gene Therapy Insights 2017; 3(10), 853-871. DOI: 10.18609/cgti.2017.082

Kozuka, He, Koo-McCoy, Kumaraswamy, Nie, Shaw, Chan, Leadbetter, Lewis, Zhong, Charmot, Balaa, King, Caldwell, Siegel. Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform. Stem Cell Reports Vol. 9 1–15 December 12, 2017. https://doi.org/10.1016/j.stemcr.2017.10.013

Gniadek, Garritsen, Stroncek, Szczepiorkowski, McKenna. Optimal Storage Conditions for Apheresis Research (OSCAR): a Biomedical Excellence for Safer Transfusion (BEST) Collaborative study. Transfusion. 2017 Dec 6. doi: 10.1111/trf.14429

Avram, M., Finney, R., Rogers, N.  Hair Transplantation Controversies.  Dermatologic Surgery. 2017; 43, S158-S162.  doi:10.1097/dss.0000000000001316

Ayoub, Lee, Driesbaugh, Anselmo, Hughes, Ferrari, Gorman, Sacks. Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair. J. R. Soc. Interface 14: 20170580 http://dx.doi.org/10.1098/rsif.2017.0580

Piscopo, N. J., Mueller, K. P., Das, A., Hematti, P., Murphy, W. L., Palecek, S. P., Capitini, C. M., Saha, K.  Bioengineering Solutions for Manufacturing Challenges in CAR T Cells.  Biotechnology Journal. 2017; 13(2).  doi: 10.1002/biot.201700095

Giulia Leoni, Alex Lyness, Patrick Ginty, Rindi Schutte, Gopalan Pillai, Gayatri Sharma, Paul Kemp, Natalie Mount, Michaela Sharpe.  Preclinical development of an automated injection device for intradermal delivery of a cell-based therapy.  Drug Delivery and Translational Research. (2017) 7:695–708.  doi: 10.1007/s13346-017-0418-z

Raffia, Nienow, Hewitt, Cookman. The role of biopreservation in cell and gene therapy bioprocessing. Cell & Gene Therapy Insights – ISSN: 2059-7800. DOI: 10.18609/cgti.2017.037

Hawkins B, Abazari A, Mathew A. Biopreservation Best Practices for Regenerative Medicine GMP Manufacturing & Focus on Optimized Biopreservation Media. Cell & Gene Therapy Insights – ISSN: 2059-7800. DOI: 10.18609/cgti.2017.035

Sinden J, Hicks C, Stroemer P, Vishnubhatla I, Corteling R. Human Neural Stem Cell Therapy for Chronic Ischemic Stroke: Charting Progress From Laboratory to Patients. Stem Cells Dev. 2017 Jul 1;26(13):933-947. doi: 10.1089/scd.2017.0009

Der, Ranabothu, Suryawanshi, Akat, Clancy, Morozov, Kustagi, Czuppa, Izmirly, Belmont, Wang, Jordan, Bornkamp, Nwaukoni, Martinez, Goilav, Buyon, Tuschl, Putterman. Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis. JCI Insight. 2017;2(9):e93009. doi: https://doi.org/10.1172/jci.insight.93009

Kayiran O. Evolution of Hair Transplantation. Clinics in Surgery Article; Department Plastic and Reconstructive Surgery Clinic, Ankara Research and Training Hospital, Turkey

Whitehouse M, Howells N, Parry M, Austin E, et al. Repair of Torn Avascular Meniscal Cartilage Using Undifferentiated Autologous Mesenchymal Stem Cells: From In Vitro Optimization to a First-in-Human Study. STEM CELLS TRANSLATIONALMEDICINE 2016; 00:00–00. DOI: 10.1002/sctm.16-0199

Fernandes MC, Dillon LA, Belew AT, Bravo HC, Mosser DM, El-Sayed NM.   Dual transcriptome profiling of Leishmania-infected human macrophages reveals distinct reprogramming signatures.  mBio (2016) 7(3):e00027-16.  doi:10.1128/mBio.00027-16.

Williams LB, Co C, Koenig JB, Tse C, Lindsay E, Koch TG.  Response to Intravenous Allogeneic Equine Cord Blood-Derived Mesenchymal Stromal Cells Administered from Chilled or Frozen State in Serum and Protein-Free Media. Frontiers in Veterinary Science. 2016; 3: 56. Published online 22 Jul 2016; doi: 10.3389/fvets.2016.00056

Baijnath S, Shobo A, Bester LA, et al.  Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI. Journal of Molecular Histology (2016) 47: 213.  doi:10.1007/s10735-016-9658-3.

Correia C, Koshkin A, Carido M, Espinha N, Saric T, Lima P, Serra M, Alves P Effective Hypothermic Storage of Human Pluripotent Stem Cell-Derived Cardiomyocytes Compatible With Global Distribution of Cells for Clinical Applications and Toxicology Testing STEM CELLS TRANSLATIONAL MEDICINE 2016; 5:658–669 DOI: 10.5966/sctm.2015-0238

Henry TD, Schaer GL, DeMaria A, Recker D, Remmers AE, Goodrich J, Patel A.  The iXCELL-DCM Trial: Rationale and Design.  Cell Transplant. 2016 Mar 22. [Epub ahead of print].  DOI:10.3727/096368916X691295.

Blázquez R, Sánchez-Margallo FM, Crisóstomo V, et al. Intrapericardial Delivery of Cardiosphere-Derived Cells: An Immunological Study in a Clinically Relevant Large Animal Model. PLoS ONE. 2016;11(2):e0149001.Published online 11 Feb 2016.  doi:10.1371/journal.pone.0149001.

Rose PT.  Hair restoration surgery: challenges and solutions. Clinical, Cosmetic and Investigational Dermatology. 2015; 8: 361-370. Published online 2015 Jul 15. doi:  10.2147/CCID.S53980

Blázquez R, Sánchez-Margallo FM, Crisóstomo V, Báez C, Maestre J, García-Lindo M, et al. (2015) Intrapericardial Administration of Mesenchymal Stem Cells in a Large Animal Model: A Bio-Distribution Analysis. PLoS ONE 10(3): e0122377. DOI:10.1371/journal.pone.0122377

Anderson MJ, David ML, Scholz M, Bull SJ, Morse D, Stevens MH, Peterson ML. Efficacy of Skin and Nasal Povidone-Iodine Preparation against mupirocin resistant MRSA and Staphylococcus aureus within the anterior nares. AAC Accepted Manuscript Posted Online 2 March 2015 Antimicrob. Agents Chemother. DOI:10.1128/AAC.04624-14

AlMulhem, N.A. (2015). Cryopreservation and Hypothermal Storage of Hematopoietic Stem Cells (Master Thesis). Retrieved from https://etd.ohiolink.edu/!etd.send_file?accession=ucin1439307244&disposition=attachment

AGE Day, Bhangra KS, Murray-Dunning C, Thanabalasundaram L, Grace N, Cameron G, Stevanato L, Sinden J, Phillips JB. Hypothermic and cryogenic preservation of artificial neural tissue made using differentiated CTX human neural stem cells in collagen gels. European Cells and Materials. Vol 29. Suppl. 3, (2015). Pg 44.

Antunes, Santos. Developing an Advanced Therapy Medicinal Product (ATMP) for the treatment of GvHD. Dissertações de Mestrado.

Cooley, J. Bio-Enhanced Hair Restoration. Hair Transplant Forum International Volume 24, Number 4

Carver GE, Locknar SA, Morrison WA, Ramanujan VK, Farkas DL. High-speed multispectral confocal biomedical imaging. Journal of Biomedical Optics 19(3), 036016 (March 2014). DOI: 10.1117/1.JBO.19.3.036016

Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, et al. Cardiopoietic Stem Cell Therapy in Heart Failure. Journal of the American College of Cardiology Vol. 61, No. 23, 2013, 0735-1097.

Petrof G, Martinez-Queipo M, Mellerio J, Kemp P, McGrath J Fibroblast cell therapy enhances initial healing in recessive dystrophic epidermolysis bullosa wounds: results of a randomized, vehicle-controlled trial. British Journal of Dermatology (2013) 169, pp1025–1033. DOI 10.1111/bjd.12599

Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, et al. (2013) Supercooling as a Viable Non-Freezing Cell Preservation Method of Rat Hepatocytes. PLoS ONE 8(7): e69334. doi:10.1371/journal.pone.0069334

Campbell SD, Crafford A, Williamson BL, Kharasch ED. Mechanism of Autoinduction of Methadone N-Demethylation in Human Hepatocytes. Published online before print June 3, 2013, doi: 10.1213/​ANE.0b013e3182918252. A & A July 2013 vol. 117 no. 1 52-60

Randelli P, Conforti E, Piccoli M, Ragone V, Creo P, Cirillo F, Masuzzo P, Tringali C, Cabitza P, Tettamanti G, Gagliano N, Anastasia L. Isolation and Characterization of 2 New Human Rotator Cuff and Long Head of Biceps Tendon Cells Possessing Stem Cell–Like Self-Renewal and Multipotential Differentiation Capacity. The American Journal of Sports Medicine. 2013. DOI: 10.1177/0363546512473572 2013.

Mathew AJ. A review of cellular biopreservation considerations during hair transplantation. Hair Transplant Forum International, 2013; 23(1):1-11.

Smith EJ, Stroemer RP, Gorenkova N, Nakajima M, Crum WR, Tang E, Stevanato L, Sinden JD, Modo M. Implantation Site and Lesion Topology Determine Efficacy of a Human Neural Stem Cell Line in a Rat Model of Chronic Stroke. Published online before print: 22 MAR 2012 DOI: 10.1002/stem.1024. Stem Cells Volume 30, Issue 4, pages 785–796, April 2012.

Spitzer TL, Rojas A, Zelenko Z, Aghajanova L, Erikson DW, Barragan F, Meyer M, Tamaresis JS, Hamilton AE, Irwin JC, Giudice LC. Perivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype. Biology of Reproduction. 2012 Feb 29; 86(2):58. Published 9 November 2011. Print 2012 Feb.; DOI:10.1095/biolreprod.111.095885.

Ginis I, Grinblat B, Shirvan MH. Evaluation of Bone Marrow-Derived MSC after Cryopreservation and Hypothermic Storage in Clinically Safe Medium. Tissue Engineering Part C: Methods. (2012) Volume 18, Number 6, 2012. DOI: 10.1089/ten.2011.0395.

Akabawy GE, Rattray I, Johansson SM, Gale R, Bates G, Modo M. Implantation of undifferentiated and predifferentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington’s disease. BMC Neuroscience (2012), 13:97; DOI:10.1186/1471-2202-13-97.

Povsic TJ, O’Connor CM, Henry T, Taussig A, et al. A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction. American Heart Journal, October 2011. Volume 162, Number 4, 654-662. DOI: http://dx.doi.org/10.1016/j.ahj.2011.07.020.

Powell RJ, Comerota AJ, Berceli SA, Guzman R, Henry TD, Tzeng E, Velazquez O, Marston WA, Bartel RL, Longcore A, Stern T, Watling S. Interim analysis results from the RESTORE-CLI, a randomized, double-blind multicenter phase II trial comparing expanded autologous bone marrow-derived tissue repair cells and placebo in patients with critical limb ischemia. Journal of Vascular Surgery. (2011) Oct;54(4):1032-41.

Woods EJ, Thirumala S. Packaging Considerations for Biopreservation. Transfusion Medicine and Hemotherapy. 2011; 38(2): 149–156. DOI: 10.1159/000326083

Lowe NJ, Lowe PL, St. Clair Roberts J. Phase IIa Open-Label Dose-Escalation Pilot Study Using Allogeneic Human Dermal Fibroblasts for Nasolabial Folds. Dermatologic Surgery. (2010). Volume 36, Issue 10, October 2010, Pages: 1578–1585. Epub 2010 Aug 16. DOI:10.1111/j.1524-4725.2010.01686.x.

Nève N, Kohles SS, Winn SR, Tretheway DC. Manipulation of Suspended Single Cells by Microfluidics and Optical Tweezers. (2010). Cellular and Molecular Bioengineering. Vol 3, No 3, 213-228. DOI:10.1007/s12195-010-0113-3.

Mathew, AJ.  I’m Losing Cell Viability and Function at Different Points in My Process, and I Don’t Know Why! BioProcess International, 8 (6): 54-7 (2010).

Yang Y, Steeg J, Honaramooz A. The effects of tissue sample size and media on short-term hypothermic preservation of porcine testis tissue. (2010). Cell and Tissue Research. 2010 May;340(2):397-406. Epub 2010 Mar 16.

Parsley WM, Perez-Meza D. Review of Factors Affecting the Growth and Survival of Follicular Grafts. (2010). J Cutan Aesthet Surg. 2010 May–Aug; 3(2): 69–75. DOI:10.4103/0974-2077.69014.

Stéphenne X, Najimi M, Sokal EM. . Hepatocyte Cryopreservation: Is it Time to Change the Strategy? (2010). World Journal of Gastroenterology. 2010 January 7; 16(1): 1-14.

Ostrowska A, Gu K, Bode DC, Van Buskirk RG. Hypothermic storage of isolated human hepatocytes: a comparison between University of Wisconsin solution and a hypothermosol platform. Archives of Toxicology. 2009 May;83(5):493-502.

Perry BC, Zhou D, Wu X, Yang FC, Byers MA, Chu TMG, Hockema JJ, Woods EJ, Goebel WS. Collection, Cryopreservation, and Characterization of Human Dental Pulp–Derived Mesenchymal Stem Cells for Banking and Clinical Use. Tissue Engineering Part C: Methods. June 10, 2008, 14(2): 149-156. DOI:10.1089/ten.tec.2008.0031.

Mathew, AJ, Snyder, KK, Baust, JM. Methods for the Effective Preservation of Cell and Tissue Samples. BioTechniques Dec 2006; p.27

Van Buskirk RG, Snyder KK, Mathew AJ, Baust JG, Baust JM. Navigating the Postpreservation Viability Fog. (2006). GEN. Nov 1, 2006 (Vol. 26, No. 19)

Baust, JM. Advances in Media for Cryopreservation and Hypothermic Storage. BioProcess International Supplement, June: 46-56 (2005).

Baust JM, Snyder KK, Mathew, AJ, Van Buskirk RG., Baust, John G. Steps to Improving Cryopreservation Outcome: Understanding key factors influencing efficacy. Bioscience Technology (2006)

Snyder KK, Van Buskirk RG, Baust JM, Mathew AJ, Baust JG. Enhanced Hypothermic Storage of Neonatal Cardiomyocytes. Cell Preservation Technology 3(1):61-74 (2005).

Cooley, J. Ischemia-Reperfusion Injury and Graft Storage Solutions. Hair Transplant Forum International Volume 14, Number 4

Snyder, K.K., Van Buskirk, R.G., Baust, J.M., Mathew, A.J., Baust, J.G. Biological Packaging for the Global Cell and Tissue Therapy Markets. BioProcessing Journal May/June: 39-46 (2004).

Baust JM, Mathew AJ, Snyder K, Liu E, Van Buskirk RG, Hardy M, Baust JG. Transplantation Diagnostics: A Preliminary Analysis Using Protein Microarray to Determine Kidney Status Prior To and Following Implantation. Cell Preservation Technology 2(2): 81-90 (2004).

Bessems M, Doorschodt BM, van Vliet AK, van Gulik TM. Preservation of rat livers by cold storage: a comparison between the University of Wisconsin solution and HypoThermosol. Ann Transplant 9(2): 35-7 (2004).

Mathew AJ, Baust JM, Van Buskirk RG, Baust JG. Cell Preservation in Reparative and Regenerative Medicine: Evolution of Individualized Solution Composition. Tissue Engineering 10(11/12): 1662-1671 (2004).

Van Buskirk RG, Baust JM, Snyder KK, Mathew AJ, Baust JG. . Hypothermic Storage and Cryopreservation – The Issues of Successful Short-term and Long-term preservation of cells and tissues. Bioprocessing International 2(10): 42-49 (2004).

Mathew AJ, Van Buskirk RG, Baust JG. Improved Hypothermic Preservation of Human Renal Cells Through Suppression of Both Apoptosis and Necrosis. Cell Preservation Technology 1(4):239-251 (2003).

Ikonomovic M, Kelly KM, Hentosz TM, Shih SR, Armstrong DM, Taylor MJ. Ultraprofound cerebral hypothermia and blood substitution with an acellular synthetic solution maintains neuronal viability in rat hippocampus. CryoLetters 22: 19-26 (2001).

Dahdah NS, Taylor MJ, Russo P, Wagerle LC. . Effects of HypoThermosol, an experimental acellular solution for tissue preservation and cardiopulmonary bypass, on isolated newborn lamb coronary vessels subjected to ultra profound hypothermia and anoxia. Cryobiology, 39, 58-68 (1999).

Mathew AJ, Hollister WR, Addona T, Baust JG, Van Buskirk RG. Vitamin E and EDTA improve the efficacy of HypoThermosol – implication of apoptosis. In Vitro and Molecular Toxicology 12(3): 163-72 (1999).

Mathew AJ, Baust JG, Van Buskirk RG. Optimization of hypothermosol for the hypothermic storage of cardiac cells – addition of EDTA. In Vitro Toxicology. 10(4): 407-415, Winter. (1997).

Van Buskirk RG, Rauch J, Robert S, Taylor MJ, Baust JG. Assessment of hypothermic storage of normal human epidermal keratinocytes (NHEK) using alamar blue. In Vitro Toxicology, 9(3), 297-303 (1996).

Simon D, Taylor MJ, Elrifai AM, et al. Hypothermic blood substitution enables resuscitation after hemorrhagic shock and 2 hours of cardiac arrest. ASAIO J. 1995 Jul-Sep;41(3):M297-300.

Taylor MJ, Bailes JE, Elrifai AM, Shih SR, Teeple E, Leavitt ML, Baust JG, Maroon JC. A New Solution for Life Without Blood: Asanguineous Low-Flow Perfusion of a Whole-Body Perfusate During 3 Hours of Cardiac Arrest and Profound Hypothermia. Circulation 91(2): 431-44 (1995).

Cook JR, Eichelberger H, Robert S, Rauch J, Baust JG, Taylor MJ, Van Buskirk RG. Cold-storage of synthetic human epidermis in HypoThermosol. Tissue Engineering 1(4): 361-77 (1995).

Rhoads LS. Use of Hypothermically Stored Keratinocyte Cultures for In Vitro Toxicology. Journal of Toxicology: Cutaneous and Ocular Toxicology. 13(3): 231-48 (1994).

Abazari A. Biopreservation considerations in the evolving field of cellular therapies. Cryobiology Volume 73, Issue 3, December 2016, Page 399. https://doi.org/10.1016/j.cryobiol.2016.09.007

Liotta A, Sandersen C, Ceusters J, Girod M, Peeters D, Bolen G. Computed tomography-guided injection of muscle-derived mesenchimal stem cells in the intervertebral disc of dogs affected by natural disc degeneration: clinical safety and intervertebral disc imaging assessment.

Rossetti T, Nichols F, Modo M.  Intracerebral Cell Implantation: Preparation and Characterization of Cell Suspensions.  Cell Transplant. 2016;25(4):645-664.  doi: 10.3727/096368915X690350

Herias M. Investigation of HypoThermosol® as a delivery medium for cardiomyocyte progenitor cellsCytotherapy 16(4):S38 (2014). DOI: http://dx.doi.org/10.1016/j.jcyt.2014.01.130

Honaramooz, Yang. Isolation of Porcine Testis Cells from Fresh and Preserved Tissues. Biology of Reproduction, Volume 81, Issue Suppl_1, 1 July 2009, Page 688. https://doi.org/10.1093/biolreprod/81.s1.688

Snyder KK, Baust JM, Van Buskirk RG, Baust JG. Improved Hypothermic Storage of Sensitive Primary Cell Systems. Cytotherapy, Vol. 7 Supp. 1, pg. 2, 2005.

Snyder KK, Baust JM, Van Buskirk RG, Baust JG. Assessment of Function and Metabolic Activity of Neonatal Cardiomyocytes Following Hypothermic Storage. Cryobiology, Vol. 47 No. 3, pg. 273, 2003. (P.L. Steponkus Crystal Award Recipient)

Mathew AJ, Baust JG, Van Buskirk RG. Enhanced hypothermic preservation of multiple human cell types. Cryobiology 43:383 (2001).

Mathew AJ, Baust JG, Van Buskirk RG. Enhanced hypothermic preservation of human renal cells. Cryobiology 43:357 (2001).

Mathew, AJ, Baust JM, Hollister WR, Al-Abdullah IH, Ricordi C, Van Buskirk RG, Baust JG. Molecular biological analysis of cell death leads to improvement in the hypothermic solution, HypoThermosol. Cryobiology 41:335-6 (2000).

Mathew AJ, Hollister WR, Baust JG, Van Buskirk RG. Continued optimization of the cold storage solution HypoThermosol and implications of apoptosis. Cryobiology 37:398-9 (1998).

Wagerle LC, Taylor MJ, Dahdah NS, Russo P.   Effects of ultraprofound hypothermia on the ex vivo contractile response of cerebral arteries: Relevance to cerebrovascular dysfunction during cardiopulmonary bypass. Cryobiology 35:346 (1997).

Taylor MJ, Snyder M, Machen L, Clark RE, Baust JG. Functional survival of isolated rabbit hearts after cold storage in HypoThermosol modified with compounds that might promote retention and repletion of high energy phosphates. Cryobiology 33:620-1, (1996).

Elrifai AM, Taylor MJ, Shih SR, Bailes JE, Kiya N, Wilberger JE, Maroon JC.  Hypothermic preservation of immature spinal cord using HypoThermosol for transplantation in the rat. Cryobiology 33:675 (1996).

Van Buskirk RG, Taylor MJ, Shen R, Tang W, Mathew AJ, Baust JG. Optimization of HypoThermosol using cultured cardiomyocytes and the fluorescent multiple endpoint assay. Cryobiology 32:590 (1995).

Van Buskirk RG, Taylor MJ, Rauch J, Roberts S, Baust JG. Preservation of synthetic human skin in HypoThermosol. Cryobiology 32:591 (1995).

Taylor MJ, Clark RE, Snyder M, Machen L, Baust JG. Static cold storage of isolated rabbit hearts in HypoThermosol: Influence of butanedione monoxime during short-term storage. Cryobiology 32:538-9 (1995).

Taylor MJ, Clark RE, Baust JG. The importance of adenosine and glutathione as components of a new hypothermic blood substitute (HypoThermosol): Evaluation of myocardial protection at 7°C using an isolated working rabbit heart model. Cryobiology 30:593-4 (1994).

Taylor MJ, Simon D, Elrifai AM, Shih SR, Bailes JE, Baust JG, Maroon JC, Diamond DL. A feasibility study in a canine model for using profound hypothermia and blood substitution with HypoThermosol to enable resuscitation after hemorrhagic shock. Cryobiology 31:592-3 (1994).

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